血清β-HCG水平与人早期胚胎发育的关系  

Impact of serum β-HCG level on human early embryonic development

作　　者：王芳[1] 孙莹璞[1] 张轶乐[1] 董方莉[1] 苏迎春[1] 郭艺红[1] 

机构地区：[1]郑州大学第一附属医院生殖医学中心,郑州450052

出　　处：《现代妇产科进展》2010年第2期95-98,共4页Progress in Obstetrics and Gynecology

摘　　要：目的：分析HCG日注射剂量不同和12h后血β-HCG水平的差异,探讨其对早期胚胎发育的影响。方法：回顾分析2008年10月2009年4月721个胚胎移植周期注射HCG后12h的血β-HCG水平。结果：按HCG日注射10000IU、8500IU和6500IU分组,随着HCG注射剂量降低,血β-HCG水平随之降低,差异有统计学意义。获卵数,成熟卵母细胞（MⅡ）率均呈降低趋势,IVF中6500IU组受精率显著低于其它两组（P〈0.05）,ICSI中各组没有显著差异;按注射HCG后12h血β-HCG值分组,IVF-ET和ICSI中,患者年龄、不孕年限、使用Gn天数和支数均无显著差异。β-HCG值〈100 mIU/ml组的体重指数最高,〉200 mIU/ml组最低,3组差异有有统计学意义（P〈0.05）。结论：HCG对卵子的最后成熟很关键,血β-HCG水平可能对胚胎质量没有显著影响,仅影响获卵数和MⅡ率。临床上对于体重指数较高的患者可适当增加HCG剂量,强调治疗方案个体化。Objective：To analysis different doses on the day of HCG injection and the differences of blood β-HCG level after 12 hours of the HCG injection and investigate the effects of HCG on the early embryonic development.Methods：The data of 721 cycles of IVF-ET which had blood β-HCG results after 12 hours of the HCG injection from Oct.2008 to Apr.2009 were analysed retrospectively.Results：Grouping analyzing the dose of injection of HCG on 10000IU,8500IU and 6500IU,with lower doses of HCG injection,blood levels of β-HCG also lower,the difference was significant.And the number of oocyte,MⅡ rate,fertilization rate showed a decreasing trend.The group of 6500IU＇s fertilization rate was significantly lower than that of the other two groups in IVF（P〈0.05）,all of these items in the ICSI had no significant difference;to divided 3 groups with blood β-HCG value,there were no significant difference between the groups of the patient＇s age,years of infertility,the doses and days of use of Gn in the IVF-ET and ICSI.β-HCG values〈100 mIU/ml group had the highest body mass index,〉200 mIU/ml in the lowest group,three groups had significant difference（P〈0.05）.Conclusion：HCG is critical for final oocyte maturation,blood β-HCG level may be no significant impact on embryo quality,the impact has been only a fewer oocytes and lower MⅡrate.Patients with higher body mass index may be appropriate to increase the dose of HCG,emphasizing individualized treatment programs.

关 键 词：人绒毛膜促性腺激素 生殖技术 辅助 胚胎发育 

分 类 号：R329.1[医药卫生—人体解剖和组织胚胎学]