2型糖尿病与结直肠癌关系的临床研究  

Clinical Research on the Relationship between Type 2 Diabetes Mellitus and Colorectal Cancer

作　　者：滕家安[1] 秦俭[2] 梁远[3] 王仁生[4] 汤春园[3] 

机构地区：[1]广西壮族自治区人民医院内分泌代谢科,南宁市530021 [2]广西壮族自治区人民医院肿瘤放疗科,南宁市530021 [3]广西壮族自治区卫生厅 [4]广西医科大学第一附属医院放疗科

出　　处：《中国肿瘤临床》2010年第3期152-155,共4页Chinese Journal of Clinical Oncology

基　　金：广西壮族自治区卫生厅科研基金资助(编号:z2007103)~~

摘　　要：目的:探讨2型糖尿病(T2DM)与结直肠癌发病和转移的关系。方法:收集广西医科大学第一附属医院2001年1月至2006年12月间收治的结直肠癌患者852例和非肿瘤患者940例的临床资料。比较两组在性别、肿瘤部位、糖尿病病程和肝转移等方面的差异,并对相关危险因素进行分析。结果:T2DM患者结直肠癌发病的危险显著高于非T2DM患者,其OR值为2.466,男性T2DM患者发生结直肠癌的危险高于女性,差异无统计学意义(OR值2.775vs2.070,P=0.394)。患有左半结肠癌的患者发生T2DM的比例最高,但与患有右半结肠癌和直肠癌者无显著性差异。T2DM病程在10～20年组发生结直肠癌的危险性最高,其0R值为4.696。T2DM合并结直肠癌患者发生肝脏转移危险性高于非T2DM合并结直肠癌患者,其OR值为2.888。结论:T2DM可能是结直肠癌发生的危险因素之一,在T2DM病程小于20年以内这种危险性随着病程的增加而增加;T2DM合并结直肠癌患者更容易发生肝脏转移。Objective： To investigate the relationship between type 2 diabetes mellitus （T2DM） and the pathogenesis and metastasis of colorectal cancer. Methods： A case-control study was performed to compare 852 colorectal cancer patients with 940 controls （patients without cancer） recruited from 2001 to 2006, with respect to their sex, cancer subsite, the course of T2DM, hepatic metastasis, smoking and drinking. Correlated risk factors were analyzed. Results： The risk of colorectal cancer was increased in patients with T2DM and the relative risk （OR） was 2.466. The OR of male patients was higher than that of female patients, but with no significant difference （2.775 vs 2.070, P=0.394）. The incidence of T2DM in patients with left hemicolon cancer was higher than that in those with right hemicolon cancer and rectal cancer, but with no significant difference between them. The colorectal cancer risk in T2DM patients with a DM course of 10 - 20 years was the highest, and the OR was 4.696. The rate of hepatic metastasis was higher in T2DM patients with colorectal cancer than that in colorectal cancer patients without T2DM and the OR was 2.888. Conclusion： T2DM may be one of the important pathogenic risk factors for colorectal cancer. The OR is increased with the extension of DM course within 20 years. Colorectal cancer patients with T2DM may be more prone to hepatic metastasis.

关 键 词：2型糖尿病 结直肠癌 临床研究 

分 类 号：R587.1[医药卫生—内分泌] R735.3[医药卫生—内科学]