我国中药来源的抗HIV天然化合物研究进展  

Advances in the study of anti-HIV natural compounds derived from traditional Chinese medicines

作　　者：张旋[1,2,3] 黄宁[1,2] 郑永唐[1] 

机构地区：[1]中国科学院昆明动物研究所中国科学院和云南省动物模型与人类疾病机理重点实验室,云南昆明650223 [2]中国科学院研究生院,北京100039 [3]昆明医学院药学院暨云南省天然药物药理重点实验室,云南昆明650031

出　　处：《药学学报》2010年第2期141-153,共13页Acta Pharmaceutica Sinica

基　　金：国家重点基础研究发展计划(973计划)资助项目(2009CB522306);国家科技重大专项"十一五"计划资助项目(2008ZX10005-005;2008ZX10001-015;2009ZX09501-029);863计划资助项目(2006AA020602);中国科学院知识创新工程重要方向资助项目(KSCX1-YW-R-24);云南省科技计划资助项目(2007BC006)

摘　　要：由于迄今仍无艾滋病(acquired immunodeficiency syndrome,AIDS)疫苗问世,抗人类免疫缺陷病毒(human immunodeficiency virus,HIV)药物仍然是艾滋病治疗的主要手段。传统中药和药用植物来源的天然化合物具有结构多样性、毒性较低、来源广泛等特点,因而在防治艾滋病方面有着独特的优势和巨大的潜力。研究者已经对天然化合物抗HIV作用进行了大量研究,并取得了可喜的成绩,发现了一些生物碱、香豆素、木脂素、黄酮类、萜类、鞣质类、多糖类、蛋白质和多肽类等天然化合物具有抗HIV的活性。然而,多数研究都是在体外试验完成的,大多数天然化合物体外抗HIV活性偏低,而且抗HIV的靶点仍不十分清楚。本文结合笔者实验室研究工作,重点介绍近年来我国传统中药来源的抗HIV活性较强的天然化合物研究进展。Anti-HIV drugs still remain as the dominant role in the treatment of acquired immunodeficiency syndrome （AIDS）, because no vaccine was found till today. Owing to structural diversity, few side effects, and abundant resources, natural compounds from traditional Chinese medicines and medicinal plants have unique advantages and good potential in prevention and treatment of AIDS. Many researchers have made great efforts in the field of anti-HIV natural compounds, and have found some natural compounds from traditional Chinese medicines with potent anti-HIV activities. These compounds can be classified into the following categories： alkaloids, coumarins, lignans, flavonoids, terpenoids, tannins, polysaccharides, proteins and peptides, and polyphenols. However, most of these researches are performed in vitro, and most natural compounds show weak anti-HIV activities and indefinite acting targets. In the paper, we reviewed some natural compounds derived from traditional Chinese medicines with potent anti-HIV activities in recent years.

关 键 词：艾滋病 人类免疫缺陷病毒 天然化合物 中药 抗HIV活性 

分 类 号：R512.91[医药卫生—内科学] R965[医药卫生—临床医学]