铜绿假单胞菌生物被膜形成的调控及治疗对策研究进展  

Research advances on regulation of Pseudomonas aeruginosa biofilm formation and its therapeutic strategies

作　　者：王文敏[1] 徐志豪[1] 

机构地区：[1]浙江大学医学院附属第二医院浙江大学呼吸疾病研究所,浙江杭州310009

出　　处：《浙江大学学报（医学版）》2010年第1期103-108,共6页Journal of Zhejiang University(Medical Sciences)

摘　　要：铜绿假单胞菌是医院内感染重要的致病菌。该菌易形成生物被膜,常给临床治疗带来很多困难。在生物被膜形成的细菌早期定植、蘑菇状结构形成以及细胞外基质生成的各个阶段均受多种分子及基因的调控,而密度感知信号系统整体调控生物被膜的形成。根据生物被膜的形成过程及调控机制,多种针对生物被膜的治疗对策已应用于临床,一些新药物和新方法也在研究之中。Pseudomonas aeruginosa is an important pathogenic bacterium of nosocomial infections. The microbe easily produce biofilm which brings us much difficulties in clinical treatment. The formation processes of biofilm,including the stages of early bacteria planting, mushroom-like structure forming and extracellular matrix producing, are regulated by a series of molecules and genes. And quorum sensing system of the microbe is responsible for regulation of the whole process of biofilm formation. According to the process of biofilm formation and the mimitat associated regulation mechanism, several anti-biofilm therapeutic strategies have been applied in clinical medicine, and some novel drugs and methods are developed.

关 键 词：假单胞菌 铜绿 生物膜 假单胞菌感染 药物疗法 

分 类 号：R378[医药卫生—病原生物学]