不稳定型心绞痛患者NT-proBNP与TNF-α水平的相关研究  

Association between N-terminal pro brain natriuretic peptide and tumor necrosis factor-α in patients with unstable angina pectoris

作　　者：牟延光[1] 鲍庆秋[1] 刘同祥[1] 

机构地区：[1]潍坊市人民医院,山东潍坊261041

出　　处：《海南医学》2010年第4期5-7,共3页Hainan Medical Journal

摘　　要：目的检测不稳定型心绞痛(UAP)患者血浆N端脑钠肽前体(NT-proBNP)、血清肿瘤坏死因子(TNF)-α浓度,探讨UAP患者血浆NT-proBNP与血清TNF-α水平相关性及其临床意义。方法选取UAP患者38例为观察组,稳定型心绞痛(SAP)患者30例作为对照组,年龄、性别相匹配的同期于我院健康查体者30例为正常对照(CON)组。测定血浆NT-proBNP和血清TNF-α浓度及左室射血分数(LVEF),分析结果并作直线相关分析。结果LVEF正常时,UAP、SAP患者血浆NT-proBNP浓度均明显高于CON组(P<0.001,P<0.02),UAP患者血浆NT-proBNP浓度显著高于SAP患者(P<0.001);UAP、SAP患者血清TNF-α浓度均明显高于CON组(P<0.001);UAP患者与SAP患者血清TNF-α浓度相比差异无统计学意义(P>0.10)。LVEF低下的UAP患者血浆NT-proBNP、血清TNF-α浓度均明显高于LVEF正常的UAP患者(P<0.002)。UAP患者的血浆NT-proBNP浓度与血清TNF-α浓度呈正相关(r=0.53,P<0.001),与LVEF呈负相关(r=-0.44,P<0.001)。结论不论LVEF正常与否,UAP患者的血浆NT-proBNP、血清TNF-α均明显升高;NT-proBNP浓度与TNF-α呈正相关,与LVEF呈负相关。除心功能外,NT-proBNP、TNF-α水平与心肌缺血有关。Objective To study the correlation between NT- proBNP and TNF-α in UAP patients, and their clinical significance. Methods 98 subjects were divided into three groups： 38 patients with UAP,30 patients with SAP, and 30 normal healthy subjects who were matched with age and sex as control. Plasma NT - proBNP concentration,serum TNF-α concentration and left ventricular ejection fraction （LVEF） were determined in all subjects. All data was analyzed and linear correlation analysis was used to determine the correlation between NT - proB- NP and other parameters. Results Under the circumstances that LVEF was normal,the concentration of plasma NT - proBNP in patients with UAP and SAP were higher than that in normal healthy subjects （P 〈0.001 ,P 〈0.02） ; the concentration of plasma NT - proBNP in patients with UAP was significantly higher than that in patients with SAP （P〈0. 001 ）. The concentration of serum TNF-α in patients with UAP and SAP were higher than normal healthy subjects （ P 〈 0. 001 ） , and there is no significant difference between UAP and SAP patients. Among the UAP patients ,the concentration of plasma NT - proBNP and serum TNF-α in patients whose LVEF below 0.50 were significantly higher than those in patients whose LVEF ≥0.50 （P 〈 0.002）. Among UAP patients, the LVEF in patients with UAP was lower than that in patients with SAP and control （ P 〈 0.001 ）. No significant difference was found between SAP and control subjects; the plasma NT - proBNP concentration was positively correlated with serum TNF-α（ r = 0. 53, P 〈 0.001 ）. The plasma NT- proBNP concentration was negatively correlated with LVEF （ r = - 0. 44, P 〈 0.001 ）. Conclusions The concentration of plasma NT - proBNP and serum TNF-α is increased significantly in patients with UAP while LVEF is normal or abnormal. NT - proBNP concentration is positively correlated with TNF-α concentration, is negatively correlated with LVEF. Besides heart function, the level of NT - proB- NP is correlated wi

关 键 词：不稳定型心绞痛 N端脑钠肽 肿瘤坏死因子 

分 类 号：R541.4[医药卫生—心血管疾病]