微小RNA在电离辐射和肿瘤中的作用  

The role of microRNA in tumor and ionizing radiation

作　　者：游洋[1] 郭海卓[2] 金顺子[2] 

机构地区：[1]吉林大学临床医学专业,长春130021 [2]吉林大学公共卫生学院卫生部放射生物学重点实验室,长春130021

出　　处：《国际放射医学核医学杂志》2009年第4期243-245,共3页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金（30870584）

摘　　要：MicroRNA（miRNA）是一类含21～25个核苷酸长度的单链小分子RNA，其在细胞生长和发育过程的调节中起到了多重作用．miRNA的突变或异位表达与多种肿瘤相关。电离辐射可以诱导miRNA的改变，从而产生致癌或抑癌效果，而且辐射诱导的miRNA表达变化还显示出细胞特异性和性别特异性。MicroRNA （miRNA）are noncoding RNA of 21-25 nucleotides that act as post-transcriptional regulators of gene expression, it plays a multiple role in the regulation of cell growth and development, miRNA mutation or ectopia expression is associated with a variety of tumor. Ionizing radiation which has a carcinogenic or tumor suppressive effect induces changes in miRNA, miRNA expression changes induced by radiation are also cell-specific and gender-specific.

关 键 词：微RNAS 肿瘤 辐射效应 

分 类 号：R818[医药卫生—放射医学] R730.2[医药卫生—临床医学]