硬膜外皮质电刺激治疗急性颅脑脑损伤的初步实验研究  

The Preliminary Experimental Study on Epidural Electric Cortical Stimulation for Acute Craniocerebral Injury

作　　者：苗树船[1] 刘绍明[2] 郑刚[2] 王晓燕[1] 

机构地区：[1]石河子大学医学院,新疆石河子832002 [2]兰州军区乌鲁木齐总医院神经外科,新疆乌鲁木齐830000

出　　处：《现代生物医学进展》2009年第23期4464-4466,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨硬膜外皮质电刺激(EECS)对急性颅脑脑损伤(ACCI)后的影响。方法:SD大鼠24只,随机分为A组(假损伤组),B组(损伤组)和C组(治疗组),侧方液压打击损伤(LFPI)大鼠脑组织建立ACCI模型后,C组给予硬膜外电刺激治疗。术后24小时处死动物,检测A组脑组织含水量、血清神经元特异性烯醇化酶(NSE)含量与B、C组上述指标的差异。结果:与A组相比,B组与C组脑组织含水量明显增加(P<0.01),与B组相比,C组大鼠脑含水量减少(P<0.05),差异有统计学意义;与A组相比,B组与C组大鼠血清NSE明显增加(P<0.01),与B相比,C组大鼠大鼠血清NSE明显减少(P<0.01),差异有统计学意义。结论:EECS可减轻ACCI后脑水肿,降低血清NSE水平,从而起到脑保护的作用。Objective：To investigate the influence of Epidural Electric Cortical Stimulation（EECS）in the brain water content and the contents of Neuron-Specific enolas（NSE）in blood serum of the rats after acute craniocerebral injury（ACCI）.Methods：24 Sprague Dawley rats were randomly divided into group A（sham injured group）,groupB（injured group）and group C（EECS treatment group）. The model of ACCI was performed by lateral fluid percussion injury（LFPI）.Animals in group C was treated by EECS after ACCI. Animals were killed at 24 hours after surgery.Then the brain water content and the contents of NSE in the blood serum were measured. Results：Compared with group A,the brain water content were significantly increased in group B and C（P〈0.01）,and compared with group B,the brain water content in group C were decreased（P〈0.05）,with statistic difference;Compared with group A,the contents of NSE in the blood serum were significantly increased in group B and C（P〈0.01）,and compared with group B,the contents of NSE in the blood serum in group C were significantly decreased,with statistic difference.Conclusion：EECS can alleviate brain edema after ACCI, attenuated the contents of NSE,accordingly,EECS play a part in neuroprotection.

关 键 词：硬膜外皮质电刺激 脑组织含水量 NSE 

分 类 号：Q95-3[生物学—动物学] R651.15[医药卫生—外科学]