苯丙胺类药物依赖与中枢胆碱能系统关系研究进展  

Research advancement on Relationship Between Dependence of Amphetamine-type Stimulants and Central Nervous Cholinergic System

作　　者：万佳[1] 洪仕君[1] 李利华[1] 邢豫明[2] 李桢[1] 李玉华[1] 

机构地区：[1]昆明医学院法医学院,云南昆明650500 [2]云南省公安厅刑事科学技术研究所,云南昆明650031

出　　处：《现代生物医学进展》2009年第23期4593-4597,共5页Progress in Modern Biomedicine

基　　金：云南省科技厅-昆明医学院联合专项项目(2008CD051)

摘　　要：苯丙胺类兴奋剂滥用可致强烈精神依赖,引起精神分裂症以及认知功能损害。研究认为中枢神经胆碱能系统参与药物依赖的调控,苯丙胺类兴奋剂依赖后导致了部分脑区乙酰胆碱释放水平、囊泡转运蛋白、胆碱能受体表达以及受体功能发生了适应性的改变,并与依赖行为的表达存在一定的关系;部分胆碱能受体抑制剂可干预依赖行为的表达。目前尚未有研究证实苯丙胺类兴奋剂对胆碱能神经元有直接损害作用。本文对苯丙胺类药物依赖与中枢胆碱能系统关系的研究进展作一综述。Abusing of amphetamine-type stimulants can cause strong psychological dependence,schizophrenia,as well as damage cognitive function.The central nervous cholinergic system has been proven involved in the regulation of the substance addiction. After administration of Amphetamine-type stimulants,it changes the release of acetylcholine,the level of vesicle transport protein, cholinergic receptor expression and receptor function in some brains.There is a certain relationship between the cholinergic neuron function changes and the expression of addictive behavior.Some of the cholinergic receptor antagonist interferes with the expression of behavioral sensitization.There is no report has shown that amphetamine-type stimulants play a direct role in damaging cholinergic neurons.The relationship between dependence of amphetamine-type stimulants with central nervous cholinergic system will be reviews.

关 键 词：苯丙胺类兴奋剂 药物依赖 中枢胆碱能系统 研究进展 

分 类 号：R971.7[医药卫生—药品] D919[医药卫生—药学]