2型糖尿病候选基因TCF7L2的研究进展  

Recent progress on the type 2 diabetes'candidate gene TCF7L2

作　　者：张琳[1] 王季猛[1] 

机构地区：[1]南华大学附属第二医院内分泌科,湖南衡阳421001

出　　处：《现代生物医学进展》2009年第23期4598-4600,共3页Progress in Modern Biomedicine

摘　　要：自发现转录因子7类似物2(TCF7L2)基因多态性与成人2型糖尿病(T2D)相关以来,该结论在不同人种中得到广泛证实。研究认为它可能通过影响肠胰岛素轴Wnt信号传导通路的胰高血糖素样肽-1(GLP-1)的表达或通过在胰岛β细胞的表达,或参与胰岛素的合成、加工、分泌,影响胰岛素敏感性等方式导致糖尿病发生。本文对该基因目前的研究成果及趋势进行相关论述。After the association of the transcription factor 7-like 2（TCF7L2）polymorphisms with type 2 diabetes had been first proposed in 2006,plenty of replication studies were successfully performed in populations of different ethnic descent.The possible mechanisms were the TCF7L2 influenced the glucagon-like peptide-1（GLP-1）in the Wnt signaling pathway,on the enteroinsular axis, or the gene had been overexpressed inβ-cells of the islets,or it influenced the insulin synthesis,processing and secretion,reduced the insulin response to glucose.This review focuses on the recent researches and advances on it.

关 键 词：转录因子7类似物2(TCF7L2) 单核苷酸基因多态性(SNPs) 2型糖尿病(T2D) 

分 类 号：R587.1[医药卫生—内分泌]