尼古丁乙酰胆碱受体促肺癌细胞增殖及抑凋亡作用  

Roles of Nicotinic acetylchoUne receptors on cell proliferation and apoptosis in lung cancer

作　　者：赵云(综述)[1] 马晓丽(审校)[1] 

机构地区：[1]山东大学医学院山东大学附属济南市中心医院中心实验室,济南250013

出　　处：《国际肿瘤学杂志》2009年第12期926-928,共3页Journal of International Oncology

基　　金：中国博士后科学基金资助项目（20080441152）

摘　　要：尼古丁乙酰胆碱受体（nAchR）除具有传导神经冲动的作用外，还能促进肺癌细胞增殖、抑制肺癌细胞凋亡。烟草成分尼古丁和亚硝胺是尼古丁乙酰胆碱受体的激动剂。当前的研究表明胡．nAchR是调节尼古丁促进肺癌细胞增殖的主要亚基。最新流行病学研究表明，编码nAchR的基因簇与肺癌发生密切相关。nAchR可能成为治疗肺癌有效的分子靶点，nAchR促进肺癌细胞增殖的研究将为治疗烟草相关肿瘤提供更大的帮助。Nicotinic acetylcholine receptors（nAChR） can promote proliferation and inhibit apoptosis of lung cancer cell except its functions on on. Nicotine and nitrosamine, the principal tobacco alkaloids, act through nAChR. Recent studies have shown that α7 is the main nAChR subunit that mediates the proliferative effects of nicotine in lung cancer cells. Epidemiological studies show that the genes encoding specific nAChR subunits are significantly associated with lung carcinogenesis, nAchR may be the effective molecular target of lung cancer treatment. Future studies involving the design of nAChR antagonists might identify novel strategies for the treatment of cancers related with tobacco.

关 键 词：尼古丁 受体 胆碱能 肺肿瘤 细胞增殖 凋亡 

分 类 号：R339.146[医药卫生—人体生理学] R734.2[医药卫生—基础医学]