桂油碱性水解制苯甲醛的工艺条件优化  

Optimization of Benzaldehyde Preparation Process by Basic Hydrolysis of Cinnamon

作　　者：黄宏妙[1] 郭占京[1] 李伟光[2] 罗佩卓[1] 周丽霞[1] 熊慧[1] 

机构地区：[1]广西中医学院.药学院,广西南宁530001 [2]广西大学化学化工学院,广西南宁530004

出　　处：《时珍国医国药》2010年第2期289-290,共2页Lishizhen Medicine and Materia Medica Research

基　　金：广西壮族自治区自然科学资金(No.0342005-3);广西高校人才小高地建设创新团队资助计划

摘　　要：目的优选桂油碱性水解制天然苯甲醛的最佳工艺条件。方法采用正交实验法,以苯甲醛的得率为指标,考察反应温度、反应时间、催化剂用量和反应加水量对苯甲醛得率的影响,优选出最佳的工艺。结果最佳制备工艺为催化剂用量为桂油用量的5%,反应时间为3 h,加水量为200 ml,反应温度为100℃。结论优化制备工艺简单、稳定、可行。Objective To explore an optimum preparation technology of benzaldehyde by basic hydrolysis of cinnamon. Methods Using the yield of benzaldehyde as the index, the effect of reaction temperature, reaction time , catalyst amount and water amount on the preparing process were studied by orthogonal design method. Results The optimum preparation procedure was as follows： reacting for 3 hours at 100℃ with 200ml water and 1：20 ratio of sodium hydroxide to cinnamon. Conclusion The optimum preparing procedure is simple and stable, and it was suitable for preparing benzaldehyde by basic hydrolysis of cinnamon.

关 键 词：桂油 天然苯甲醛 碱性水解 正交试验 

分 类 号：R284.3[医药卫生—中药学]