乳康舒饮片汤剂与其免煎配方颗粒的指纹图谱比较  

Comparative Study on Fingerprints of Traditional Herbs Decoction and Compatible Granules of Rukangshu by HPLC

作　　者：孔铭[1] 钱大玮[2] 朱玲英[1] 

机构地区：[1]江苏省中医药研究院,江苏省现代中药制剂工程技术研究中心,江苏南京210028 [2]南京中医药大学江苏省方剂研究重点实验室,江苏南京210046

出　　处：《时珍国医国药》2010年第2期398-400,共3页Lishizhen Medicine and Materia Medica Research

基　　金：江苏省社会发展资助项目(No.BS2003055)

摘　　要：目的研究乳康舒传统合煎液与其经过分煎制成的免煎配方颗粒混合物的化学成分的差异。方法采用HPLC色谱指纹图谱法,比较乳康舒免煎配方颗粒和乳康舒汤剂两者指纹图谱的差别,并通过相似度软件分析两者的相似性。结果乳康舒配方颗粒中共出13个色谱峰,确认出其中的12个色谱峰。乳康舒合煎液和混合免煎配方颗粒指纹图谱的相关系数为0.839。结论乳康舒合煎液同其分煎制成的免煎配方颗粒中的主要化学成分组成基本相同,其共有成分比例相近。Objective To study the difference in main chemical composition between traditional herbs decoction and compatible granules of Rukangshu. Methods HPLC was adopted to compare the fingerprints of traditional herbs decoction and compatible granules of Rukangshu, and computer aided similarity evaluation was applied to analyze similarity. Results There were 13 peaks in the fingerprints of compatible granules of rukangshu and 12 peaks were ascertained the source. The correlation of both HPLC fingerprint was 0. 839. Conclusion The main chemical substances and the composition ratio of traditional herbs decoction and compatible granules of Rukangshu are similar.

关 键 词：乳康舒 配方颗粒 指纹图谱 高效液相色谱 

分 类 号：R284.1[医药卫生—中药学]