均匀设计法优化超临界二氧化碳萃取川东獐牙菜总酮工艺的研究  

Optimization of the Extraction of Total Xanthones from Swertia davidi Franch by Supercritical CO_2 with Uniform Design

作　　者：周慧[1] 胥秀英[1] 郑一敏[1] 韩玉梅[1] 傅善权[1] 李杰[1] 曾品涛[1] 王琳琳[1] 

机构地区：[1]重庆理工大学化学与生物工程学院,重庆400050

出　　处：《时珍国医国药》2010年第2期406-407,共2页Lishizhen Medicine and Materia Medica Research

基　　金：重庆市教委自然科学基金(No.KJ050607)

摘　　要：目的探讨超临界CO2流体萃取川东獐牙菜中总酮的最佳工艺条件。方法以总酮的含量为指标,采用均匀设计法对影响萃取结果的主要因素进行考察。结果夹带剂流速对萃取结果影响最为显著。最佳萃取工艺参数为:萃取压力35 Mpa,萃取温度50℃,乙醇浓度100%,夹带剂流速4.5 ml.min-1,萃取率达到0.425%。结论超临界CO2流体萃取川东獐牙菜总酮是一种切实可行的方法。所得萃取产物中酮的含量高,萃取时间短,操作简便。Objectlve To study the optimal supercritical -fluid extraction technique from total xanthones Swertia davidi Franch. Methods The uniform design method was used in experience arrangement. The yield rate of total xanthones was as indicator. Resuits The optimal extraction conditions were as follows ： temperature at 50℃, pressure at 35 MPa, velocity of flow 4.5ml·min^-1, 100% ethanol（ volume fraction） as entrainer. The extraction rate was as high as 0. 425%. Conclusion This technique is easy, convenient and workable, and can provide theoretical support for production.

关 键 词：超临界CO2流体萃取 均匀设计法 川东獐牙菜 总酮 

分 类 号：R284.2[医药卫生—中药学]