氯磷定胃内灌注抢救急性有机磷农药中毒的解毒作用  

Pralidoxime chloride perfusion intragastric acute organophosphorus pesticide poisoning detoxification

作　　者：顾家富 齐梅英 

机构地区：[1]郸城县第二人民医院,河南郸城477150

出　　处：《中外医学研究》2010年第3期7-8,共2页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的探讨急性有机磷农药中毒时早期氯磷定胃内灌注治疗及效果j方法抢救急性口服有机磷中毒者立即插胃管注入氯磷定注射液5g或更大剂量洗胃，在洗胃的同时给予负荷量氯磷定注射液静脉注射，尽快达到阿托品化．．对症支持治疗；对照组的治疗除不进行氯磷定注射液胃内灌注外，其他均相同。结果治疗组98例患者，治愈96例（98％），住院时间、胆碱酯酶恢复正常值的时间、呼吸衰竭发生倒数、中间综合征发生倒数、死亡例数、阿托品用量均比对照组显著减少，差异具有统计学意义（P〈0．01）。结论抢救急性有机磷农药中毒时早期足量应用氯磷定注射液胃内灌注阻断毒物的继续吸收是抢救成功的关键。Objective To investigate the acute organophosphorus pesticide poisoning pralidoxime chloride when early treatment and the effect of intragastric infusion. Methods Of oral acute organophosphate poisoning stomach cannula immediately injected pralidoxime chloride injection dose of 5 g or more of gastric lavage in gastrolavage load at the same time give pralidoxime chloride injection intravenous injection of atropine to achieve as soon as possible. Symptomatic supportive care ;control greop without treatment in addition to pralidoxime chloride injection intragastric infusion, the other were the same. Results 98 eases of the treatment group,96 eases of cure （98%） , hospitalization time, the restoration of normal eholinesterase time,respiratory failure occurred in a few cases, the number of cases of intermediate syndrome occurs, the number of death cases., the amount of atropine than a significant reduction in the control group, the difference was statistically significant（ P 〈 0.01 ）. Conclusion Acute organophosphorus pesticide poisoning when applied early enough pralidoxime chloride injection intragastric infusion to continue blocking the absorption of the poison is the key to success in the rescue.

关 键 词：氯磷定 有机磷农药中毒 胃内灌注治疗 

分 类 号：R595.4[医药卫生—内科学] R725.954[医药卫生—临床医学]