梗死体积与早期血清中OX-LDL、HS-CRP含量水平的关系  

THE RELATIONSHIP BETWEEN THE VOLUME OF ACUTE CEREBRAL INFARCTION AND THE SERUM LEVELS OF OX-LDL AND HIGH-SENSITIVITY C-REACTIVE PROTEIN

作　　者：唐淑花[1] 夏强[1] 李新立[1] 冯继贞[1] 刘群才[1] 李强[1] 

机构地区：[1]中国人民解放军第159医院神经内科,河南驻马店463008

出　　处：《泸州医学院学报》2010年第1期45-47,共3页Journal of Luzhou Medical College

摘　　要：目的:观察氧化低密度脂蛋白(OX-LDL)、高敏C-反应蛋白(HS-CRP)在不同梗死体积早期血清中的含量变化,探讨其对急性脑梗死(ACI)预后生活质量的影响。方法:采用酶联免疫吸附试验(ELISA)双抗体夹心法、微粒化增强免疫固定试验测定36例梗死体积15cm3以上、78例75cm3以上、23例135cm3以上ACI患者入院第2d血清中OX-LDL、HS-CRP含量水平,另设30例健康人作对照。同时对所有病人入、出院时均进行神经功能缺损程度(NDS)评分,观察OX-LDL、HS-CRP不同含量水平对ACI预后生活质量的影响。结果:与对照组比较,梗死体积15cm3以上者血清中OX-LDL、HS-CRP含量明显升高(P<0.01);75cm3以上较15cm3以上者显著升高(P<0.01),但低于135cm3以上者(P<0.01)。同等条件下ACI患者早期血清中OX-LDL、HS-CRP含量水平越高,预后生活质量越下降(P<0.05)。结论:ACI患者早期血清中OX-LDL、HS-CRP含量明显升高,梗死体积越大其含量越高;OX-LDL、HS-CRP含量越高,其预后生活质量越差。Objective： To investigate the changes of the levels of OX-LDL and High-sensitivity C-reactive protein（HS-CRP） in patients with different volumes of acute cerebral infartion（ACI）. Methods： OX-LDL and HS- CRP were measured by ELISA（ sandwich technique） in 137 patients with ACI on the 2nd day after admission, and in 30 controls. All patients were scored according to the nervous defect standard （NDS） on admission and before discharge. Results ： The levels of OX-LDL and HS-CRP in ACI group were significantly higher than those in control group （P〈0.01）. The levels of OX-LDL and HS-CRP in patients with medium cerebral infarction were significantly higher than those in patients with small cerebral infarction （P〈0.01） and lower than those in patients with large cerebral infarction （P〈0.01）. The more severe neurologic impairment the patients suffered, the higher the levels of OX-LDL and HS-CRP were. Conclusion ： The content of OX-LDL and HS-CRP in patients with ACI may have synergie effect on the volumes of ACI.

关 键 词：急性脑梗死 体积 氧化低密度脂蛋白 高敏C-反应蛋白 

分 类 号：R473[医药卫生—护理学]