可溶性细胞间黏附分子及可溶性血管细胞黏附分子与代谢综合征各组分的关系及其致动脉粥样硬化作用  

Association of Soluble Intercellular Adhesion Molecule-1 and Soluble Vascular Cell Adhesion Molecule-1 with Constituents of Metabolic Syndrome and Its Role in Induction of Atherosclerosis

作　　者：肖立平[1] 李海涛[2] 

机构地区：[1]华北煤炭医学院研究生部,河北省唐山市063000 [2]华北煤炭医学院附属医院心内科

出　　处：《中国全科医学》2010年第5期558-560,共3页Chinese General Practice

摘　　要：可溶性细胞间黏附分子-1(soluble intercellular adhesion mo1ecule-1,sICAM-1)和可溶性血管细胞黏附分子-1(soluble vascular cell adhesion molecule-1,sVCAM-1)介导单核细胞向内皮细胞黏附,在动脉粥样硬化(atherosclerosis,AS)的形成和发展中起了重要作用。代谢综合征各组分通过诱导sICAM-1、sVCAM-1的表达,促进了AS的发展。抑制黏附分子及其介导的黏附作用可望成为MS个体以及具有MS组分而尚未诊断为MS的个体预防和减慢向AS发展的有效手段。本文就sICAM-1和sVCAM-1与MS各组分的关系及其致AS作用进行综述。Soluble intercellular adhesion molecule-1（sICAM-1） and soluble vascular cell adhesion mo1ecule-1（sVCAM-1）,leading monocytes to adhere to endothelial cells,play a crucial role in the development and progression of atherosclerosis（AS）.Metabolic syndrome（MS） constituents induce the expression of sICAM-1 and sVCAM-1 to promote AS development.Inhibition of adhesion molecule and its induced adhesion is expected to become an effecitive method to prevent MS individuals or individuals with MS constituents undiagnosed as MS from developing to AS or to slow it down.This paper reviews the relationship of sICAM-1 and sVCAM-1 to MS constituents and its role in AS induction.

关 键 词：代谢综合征 可溶性细胞间黏附分子-1 可溶性血管细胞黏附分子-1 动脉粥样硬化 

分 类 号：R589[医药卫生—内分泌]