甲型H1N1流感患者T细胞亚群的变化特点(附67例报告)  

Changes of T Lymphocyte Subsets in Sixty-seven Patients with Influenza A (H1N1)

作　　者：张琦[1] 凌伟[2] 李鑫[2] 卢联合[2] 陈志海[2] 李兴旺[2] 

机构地区：[1]清华大学医院内科,北京市100084 [2]北京地坛医院感染科,北京市100015

出　　处：《中国全科医学》2010年第6期571-573,共3页Chinese General Practice

摘　　要：目的探讨甲型H1N1流感患者发病期和恢复期T细胞亚群变化特点。方法采用美国BD公司生产的Fascalibur流式细胞仪检测甲型H1N1流感患者发病期及恢复期外周血CD4+、CD8+T淋巴细胞,并与对照组进行比较。结果研究组发病期、恢复期和对照组CD4+T、CD8+T淋巴细胞绝对数比较,差异均有统计学意义(P<0.05)。其中研究组发病期CD4+T、CD8+T淋巴细胞绝对数明显低于恢复期和对照组,差异有统计学意义(P<0.05);恢复期与对照组CD4+T淋巴细胞绝对数间差异无统计学意义(P>0.05),但恢复期CD8+T淋巴细胞绝对数多于对照组,差异有统计学意义(P<0.05)。不同治疗方法的患者治疗前后CD4+、CD8+T淋巴细胞绝对数的差值间差异无统计学意义(P>0.05)。结论甲型H1N1流感患者发病期细胞免疫功能显著下降,4种治疗方法对T细胞亚群的影响没有差异,临床工作中要注意危重并发症的防治。Objective To study the changes of T lymphocyte subsets in patients with influenza A （ H1 N1 ） . Methods The CD4^＋ and CD8^＋ T lymphocytes were counted in eruption and recovery stages in patients with influenza A （H1N1） and healthy controls using flow cytometer （ FCM ）. The results were compared between these two groups. Results The amounts of CD4^ ＋ and CD8^ ＋ T lymphocytes were significantly different among the influenza A （ H1 N1） patients in eruption and recovery stages and the healthy controls （ all P 〈 0. 05 ） . The amounts of CD4^＋ T lymphocyte and CD8^＋ T lymphocyte of influenza A （ H1N1 ） patients in the eruption stage was significantly lower than those in the recovery stage and those of the healthy controls （ P 〈 0. 05 ） . The amount of CD4^ ＋ T lymphoeytes in patients in recovery stage was not significantly different from that of healthy controls （ P 〉 0. 05 ）, while the amount of CD8^＋ T lymphocyte of patients in recovery stage was significantly larger than that of the healthy controls （ P 〈 0. 05 ） . The amounts of CD4^＋ T lymphocyte and CD8^＋ T lymphocyte were not significantly different among patients receiving different treatment strategies （ P 〉 0. 05 ） . Conclusion The cellular immune function decreased in the eruption stage of influenza A （ H1N1） . Treatment methods does not affect T lymphocyte subsets. Severe complications should be carefully monitored and managed in clinical practice.

关 键 词：流感病毒A型 H1N1亚型 T淋巴细胞 免疫功能 

分 类 号：R511.7[医药卫生—内科学]