原发性高血压患者血压水平与抵抗素关系的研究  

Relationship between Essential Hypertension and Resistin Levels

作　　者：黄寰[1] 陈静平[1] 冯嘉贤[1] 贺佩兰[1] 巫少荣[2] 李自成[2] 张云 何淑云 

机构地区：[1]广州医学院羊城医院,广东省广州市510140 [2]暨南大学第一附属医院心内科 [3]广州市荔湾区昌华社区卫生服务中心

出　　处：《中国全科医学》2010年第6期604-606,共3页Chinese General Practice

摘　　要：目的对原发性高血压不同血压水平患者进行血清抵抗素(RES)检测,探讨RES水平与高血压的发生、发展之间的关系。方法选择研究对象共154例,其中原发性高血压患者114例,根据血压水平的高低分为高血压1级组(H1)、高血压2级组(H2)和高血压3级组(H3),正常血压组(H4,对照组)40例,检测各组受检者的RES、血总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBS);并计算体质指数(BMI)。分析影响RES的因素。结果(1)4组受检者RES水平间差异有统计学意义(F=8.96,P=0.000),其中H4组较H3组水平低,H1、H2组也较H3水平低,差异有统计学意义(P=0.000);但H4、H1、H2组两两之间差异无统计学意义(P均>0.05);(2)RES与收缩压(SBP)(r=0.201,P=0.012)、舒张压(DBP)(r=0.290,P=0.000)均呈正相关,与高密度脂蛋白胆固醇(r=-0.172,P=0.033)呈负相关;(3)按逐步引入-剔除法以RES为应变量,以年龄(AGE)、BMI、SBP、DBP、TC、TG、HDL-C、LDL-C、FBS为自变量进行多元线性回归分析,RES与DBP、HDL-C之间呈直线关系,DBP、HDL-C是影响RES水平的独立危险因素;以SBP、DBP分别为应变量,RES、TC、FBS及AGE是影响SBP、DBP的独立危险因素。结论(1)血清RES水平在正常血压人群要明显比原发性高血压人群低;高血压1级人群水平要明显比高血压3级人群低。(2)血清RES水平与收缩压、舒张压呈正相关,与HDL-C呈负相关;(3)血清RES的升高是原发性高血压发生和发展进程中的重要影响因素。Objective To explore the relationship between essential hypertension and resistin levels. Methods Totally 154 outpatients including 40 patients with normal blood pressure （H4 group ） and 114 patients with essential hypertension （EH group） were enrolled in this study. The EH group were chopped into 3 groups according to the blood pressure levels： H1 group （Grade 1 hypertension）, H2 group （Grade 2 hypertension）, and H3 group （Grade 3 hypertension. Serum resistin, blood cholesterol （TC）, trigeylglycerol （TG）, high-density lipoprotein （HDL）, low-density lipoprotein （LDL）, and fasting plasma glucose were examined in each group. Body mass index （BMI） was. calculated. Factors that may influence the resistin levels were analyzed. Results The resistin level of H3 group was significantly higher than that in H4 group （ F = 8. 959, P = O. 000） , and also significantly higher than those in H1 and H2 groups （P = 0. 000 ）. However, such difference was not found between H4, H1, and H2 groups （ all P 〉 0. 05）. （2） Resistin levels were positively correlated with systolic blood pressure （SBP） （r = 0. 201, P =0. 012） and diastolic blood pressure （DBP） （r = 0. 290, P =0. 000）, and were negatively correlated with high - density lipoprotein cholesterol （ r = - 0. 172, P ： 0. 033 ）. By using the gradual introduction - excluding method with resistin as the dependent variable and age, BMI, SBP, DBP, TC, TG, HDL, LDL, and FBS as the independent variables, multiple linear regression analysis showed that RES had a linear relation with DBP and HDL, and DBP and HDL are independent factors that affected resistin levels. When using SBP and DBP as the dependent variable seperately, resistin, TC, FBS, and age are independent factors that affected the levels of SBP and DBP. Conclusion Serum resistin levels is lower in normal blood pressure population than in patients with essential hypertension. Serum resistin levels is positively correlated with SBP and DBP and negativ

关 键 词：原发性高血压 抵抗素 

分 类 号：R544.11[医药卫生—心血管疾病]