三唑农药的手性拆分及对映体的转化  

Chiral Separation and Enantiomerization of Triazole Pesticides

作　　者：李朝阳[1] 张艳川[2] 李巧玲[2] 王未肖[1] 李景印[1] 

机构地区：[1]河北科技大学理学院应化系,石家庄050018 [2]河北科技大学生物工程学院,石家庄050018

出　　处：《分析化学》2010年第2期237-240,共4页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金(No.20707005);教育部留学回国人员科研启动基金(No.教外司留[2009]1001号)资助项目

摘　　要：利用Chiralcel OJ-H和Chiralcel OD-H手性柱对烯唑醇、三唑酮和三唑醇的手性拆分进行了研究,进一步测定了烯唑醇和三唑酮对映体的旋光性质,据此确定了两种农药对映体的绝对构型,在此基础上结合三唑酮转化为三唑醇的还原实验确定了三唑醇4个对映异构体的绝对构型。考察了几种三唑农药在有机溶剂和缓冲溶液中的手性稳定性,其中三唑酮在甲醇、乙醇和水中存在明显的对映体转化行为,而烯唑醇和三唑醇则是手性稳定的,升高温度及碱性环境会加快三唑酮的对映体转化。The chiral separation of three triazole pesticides,i.e.diniconazole,triadimefon and triadimenol was studied on a Chiralcel OJ-H and a Chiralcel OD-H HPLC chiral columns.The optical rotation quality of diniconazole and triadimefon enantiomers was measured and the absolute configurations of individual enan-tiomers were further concluded.On this basis,the absolute configurations of the four triadimenol stereoisomers were deduced via the reductive experiment of triadimefon to triadimenol.Furthermore,the chiral stability of the three triazole pesticides in organic solvents and buffer solutions was investigated.The results showed the obvious enantiomerization was observed as for triadimefon in methanol,ethanol and water,whereas dinicona-zole and triadimefon were chiral stable in organic solvents and water.The enantiomerization of triadimefon would be accelerated at higher temperature and in alkaline media.

关 键 词：三唑农药 手性拆分 对映体转化 旋光 绝对构型 

分 类 号：X592[环境科学与工程—环境工程]