三叶香茶菜的保肝作用及其作用机制研究  

Study on Liver Protection and Its Mechanich of Isodon ternifolia(D. Don) Kudo

作　　者：周至品[1,2] 王勤[3] 李爱媛[3] 

机构地区：[1]广西中医学院附属瑞康医院,广西南宁530001 [2]南方医科大学,广东广州510315 [3]广西中医学院,广西南宁530001

出　　处：《安徽农业科学》2010年第4期1844-1845,1859,共3页Journal of Anhui Agricultural Sciences

基　　金：广西科技厅科技攻关项目(桂科攻0537025-3B)

摘　　要：[目的]比较三叶香茶菜地上部分和地下部分的保肝降酶作用,研究其可能的保肝作用机制。[方法]采用四氯化碳(CCl4)小鼠急性肝损伤动物模型,卡介苗(BCG)和脂多糖(LPS)诱导的小鼠免疫性肝损伤模型,观察三叶香茶菜地上部分和地下部分水提物对小鼠血清谷丙转氨酶(ALT)活力、谷草转氨酶(AST)活力、总超氧化物歧化酶(T-SOD)活力和脂质过氧化物(MDA)、白细胞介素6(IL-6)含量的影响。[结果]三叶香茶菜地上部分和地下部分可明显降低CCl4急性肝损伤小鼠血清ALT、AST活力和MDA含量,提高T-SOD活力(P<0.01,P<0.05),能显著降低BCG+LPS诱导的免疫性肝损伤小鼠血清ALT活力和MDA含量,明显提高小鼠血清T-SOD活力(P<0.01,P<0.05);三叶香茶菜地上部分和地下部分对ALT、AST活力和MDA含量的影响无显著性差异(P>0.05)。[结论]三叶香茶菜地上部分和地下部分具有明显的保肝作用,两者的作用效果相当。[Objective]The study aimed to study and compare the protective effects of the plant shoots and the roots of the cultural Isodon ernifolia（D.Don） Kudo on experimental liver injury induced by CCl4 and BCG ＋ LPS in mice.[Methodl]Applied experimental liver injury induced by CCl4 and BCG ＋ LPS in mice to observe the effects the plant shoots and the roots of the cultural Isodon ternifolia（D.Don） Kudo on the activity of ALT,AST and T-SOD in blood serum of mice,and the levels of MDA,IL-6.[Result]The plant shoots and the roots of the cultural Isodon ternifolia（D.Don） Kudo could markedly inhibit the activities of ALT,AST and the levels of MDA,IL-6,increased the activities of TSOD in blood serum of mice whose livers injured by CCl4 and BCG ＋ LPS.[Conclusion]The plant shoots and the roots of the cultural Isodon ternifolia（D.Don） Kudo have good protective effects on experimental liver injury induced by CCl4 and BCG ＋ LPS in mice,respectively,and their both effects were similar.

关 键 词：三叶香茶菜 保肝作用 比较 

分 类 号：S567.239[农业科学—中草药栽培]