3～6岁儿童反复上呼吸道感染的多因素非条件Logistic回归分析  

Multi-Factor Non-Conditional Logistic Regression of Recurrent Upper Respiratory Tract Infections in Children Aged 3 to 6 Years Old

作　　者：卫重侠[1] 席卫平[2] 杨建平[2] 任丽丽[2] 阎亚琼[2] 乔阳[2] 朱玲[2] 李若玲[2] 刘晓莉[2] 王颎[2] 

机构地区：[1]山西医科大学,山西太原030001 [2]山西省儿童医院(山西省妇幼保健院)

出　　处：《中华妇幼临床医学杂志（电子版）》2010年第1期14-17,共4页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：2009年山西省卫生厅科技攻关计划项目(200931)~~

摘　　要：目的了解影响3～6岁反复上呼吸道感染(recurrent upper respiratory tract infections,rURTIs)儿童的饮食、家庭育儿方式及生活环境因素等,探讨导致反复上呼吸道感染的危险与保护因素,为制定防治措施提供依据。方法选择2008年12月至2009年5月在山西省儿童医院(山西省妇幼保健院)儿童保健科因呼吸系统疾病就诊的3～6岁儿童230例为研究对象。其中,男性儿童为151例(65.7%),女性为79例(34.3%)。按照2008年中华医学会儿科学分会呼吸学组对上呼吸道感染的诊断标准确诊230例儿童中,118例为反复上呼吸道感染患儿(纳入病例组),其中男性患儿为82例(69.5%),女性为36例(30.5%)。另外112例为同期在山西省儿童医院(山西省妇幼保健院)儿保科健康检查的3～6岁正常儿童,将其纳入对照组,其中男性儿童为69例(61.6%),女性为43例(38.4%)[本研究遵循的程序符合山西省儿童医院(山西省妇幼保健院)人体试验委员会制定的伦理学标准,得到该委员会批准,分组征得受试对象监护人的知情同意,并与其签署临床研究知情同意书]。采取问卷调查单因素与多因素非条件Logistic回归分析方式,分析病例组、对照组儿童的一般人口学特征、营养状况、家庭育儿方式及生活环境等因素,确定影响反复上呼吸道感染的危险因素与保护因素。结果影响3～6岁儿童反复上呼吸道感染的因素有①危险因素:每周摄入蔬菜1～3次[OR=5.195,95%CI(1.193,22.624)],入托[OR=5.642,95%CI(1.149,27.702)],反复上呼吸道感染病史[OR=8.129,95%CI(2.725,24.256)],每日户外活动少于30 min[OR=4.583,95%CI(0.857,24.499)]或不足2 h[OR=5.291,95%CI(1.576,17.763)]。②保护因素:父亲文化程度高中以上[OR=0.134,95%CI(0.034,0.527)],每周摄入水果4～6次[OR=0.231,95%CI(0.069,0.775)],年使用抗生素低于3次[OR=0.028,95%CI(0.003,0.303)]。③反复上呼吸道感染病史和水果、蔬菜类摄入及入托之间存在交互作用。结[Abstract] Objective To investigate the impact of diet, the way of parenting and iiving environment on recurrent upper respiratory tract infections （rURTIs） in children, and to discuss risk and protective factors in order to explore new method for taking prevention measures. Methods From December 2008 to May 2009, a total of 230 children aged 3 to 6 years old who were admitted in the Department of Child Health Care, Children Hospital of Shanxi, including 151 boys （65.7~） and 79 girls （34.3~）. Among those 230 children, 118 children were diagnosed as recurrent upper respiratory tract infections （case group） according to the diagnostic criteria made by Subspecialty Group of Respiratory Diseases, the Society of Pediatrics, Chinese Medical Association, including 82 boys （69.5~） and 36 girls （30.5~）. At the same time, another 112 normal children aged 3 to 6 years old from the same hospital were included into control group, including 69 boys （61.6%） and 43 girls（38.4~）. Informed consent was obtained from all participates. The general demographic characteristics, nutritional status, ways of parenting and living environment were analyzed between two groups by single factor and multi factor non conditional Logistic regression analysis approach in order to explore risk and protective factors of recurrent upper respiratory tract infections. Results The main influencing factors of recurrent upper respiratory tract infections aged 3 to 6 years old included, （1） Risk factors： Vegetable consumption at least third times per weekEOR=5.195,95CI（1. 193,22. 624）1, nursery school [OR 5. 642, 95% CI （ 1. 149, 27. 702）1, history of recurrent upper respiratory tract infectionsEOR 8. 129, 95%CI（2. 725, 24. 256）1, outdoor activity less than 30 minutes a day （OR=4. 583, 95%CI（0. 857,24. 499）1 or less than 2 hours a day EOR 5. 291,95%CI（1. 576,17. 763）1. （2）Protective factors： Education level of father EOR=O. 134,95%CI（0. 034,0. 527）], fruit consumption at least six times

关 键 词：反复上呼吸道感染 病例对照研究 儿童 LOGISTIC回归 多因素分析 

分 类 号：R725.6[医药卫生—儿科]