高血压合并糖耐量异常的早期干预分析  

Outcome and Influencing of Intensive Intevention in Hypertension Patients Accompanied by Impaired Glucose Tolerance

作　　者：林海真[1] 钟惠娟[1] 侯维宁[1] 林卓慧[1] 张立建[1] 潘锦汉[1] 陈端[1] 

机构地区：[1]广东省广州医学院荔湾医院心血管内科,510170

出　　处：《中华全科医学》2010年第3期305-306,共2页Chinese Journal of General Practice

摘　　要：目的探讨对原发性高血压合并糖耐量异常(IGT)患者进行高血糖干预治疗的转归。方法筛选原发性高血压合并IGT患者(45～80岁)121人,分两组(干预组,对照组),两组均给予降压及调脂等治疗以及生活方式指导,干预组同时给予二甲双胍治疗餐后高血糖,随访2年。结果2年后干预组无一例发展为糖尿病,对照组13例(21.7%)进展为糖尿病。对照组心衰及脑卒中的发病率均高于干预组。结论原发性高血压合并IGT的患者在降压调脂等综合治疗基础上早期干预餐后高血糖,可显著减少新发糖尿病的发生率,降低心脑血管事件的发生率,提示重视筛查IGT及早期干预的重要性。Objective To investigate the outcome of intensive intervention in hypertension patients accompanied by impaired glucose tolerance（IGT）. Methods The hypertension patients with impaired glucose tolerance were randomly assigned to either a routine care group（ control group） or to an intensive intervention group. The two groups received general dietary and exercise advice and were advised to take antihypertensive agents, Lipid-regulatingagents if necessary. Metformin was also administrated in the intervention group. Results None in the intensive group developed overt diabetes mellitus while 13 （21.7%） in the control group did after intervention for 2 years, the percentage of patients being hospitalized with cardiovascular events was significantly higher in the control group than those in the intensive group （ P 〈 0.05 ）. Conclusion The intensive intervention could significandy decrease the conversion rate of IGT to diabetes mellitus and significantly decrease incidence of cardiovascular events. IGT was the best opportunity for hyperglucemia intervention for the CVD.

关 键 词：高血压 IGT 早期干预 糖尿病 心脑血管事件 

分 类 号：R544.1[医药卫生—心血管疾病] R587.1[医药卫生—内科学]