Lipo-PGE_1对2型糖尿病肾病血清TNF-α及TGF-β_1的影响  

Effect of lipo-prost aglandine E_1 parenteral solution on serum TNF-α,TGF-β_1 in patients with type 2 diabetic nephropathy

作　　者：路娜[1] 王敏河[2] 郑华[3] 

机构地区：[1]胜利油田机关医院内分泌科,山东东营257000 [2]胜利油田中心医院内分泌科,山东东营257000 [3]胜利油田孤岛医院,山东东营257231

出　　处：《现代医药卫生》2010年第6期817-819,共3页Journal of Modern Medicine & Health

摘　　要：目的:探讨脂微球前列腺素E1(Lipo-PGE1)对2型糖尿病肾病(DN)患者血清炎性因子的影响及其治疗2型DN的机制。方法:2型DN患者61例分为治疗组和对照组。采用常规降糖、控制血压,病情稳定2周后,对照组采用疏血通治疗2周。治疗组采用Lipo-PGE110μg加入生理盐水20ml,静脉10min缓慢推入,每日1次。治疗前后检测患者空腹血糖(FPG)、糖化血红蛋白(HbA1c)、尿素氮(BUN)、血肌酐(Scr)、血清肿瘤坏死因子-α(TNF-α)、转化生长因子-β1(TGF-β1)、24h尿白蛋白定量(Uab)。结果:治疗后治疗组血TNF-α、TGF-β1、24h尿白蛋白定量、Scr、BUN较对照组明显下降,差异有极显著性(P<0.01)。结论:Lipo-PGE1对2型DN患者有显著降低血清TNF-α、TGF-β1及尿白蛋白的作用,有效改善肾功能。Objective：To observe the effect of lipo-prostaglandin E1 （PGE1） parenteral solution on serum cytokines in the patients with 2 type diabetic nephropathy and to study the curing mechanism of lipo-PGE, parenteral solution to diabetic nephropathy.Methods： Total 61 patients with type 2 diabetic nephropathy were randomly divided into treatment group and control group.We used the conventional way to fall sugar and control blood pressure. 2-week stability later,the control group was treated with Shuxuetong intravenously. The treatment group was treated with lipo-PGE1 10 μg in NS 20 mL intravenously one time every day . Each course lasted for two weeks. We observed and recorded the changes of serum inflammatory factors tumor necrosis factor-alpha（TNF-α）, transforming growth factor-betal（TGF-β1）, serum creatinine （Scr）, blood urea nitrogen （BUN）,24h urine albumin and fasting plasma glucose （FPG.）.Results：After the treatment, the level of TNF-α,TGF-β1,24h urine albumin, Scr and BUN in the treatment group was significantly reduced as compared with the control group （P〈0.01）.Conclusion：Lipo-PGE1 can obviously reduce the level of serum TNF-α,TGF-β1 in the type 2 diabetic nephropathy patients,which may be related with its actions in inhibiting the production of inflammatory cytokines. Lipo-PGE1 can obviously decrease urine albumin and improve kidney function.

关 键 词：脂微球前列腺素E1 糖尿病肾病 肿瘤坏死因子-α 转化生长因子-Β1 

分 类 号：R5[医药卫生—内科学]