骨组织工程支架材料聚磷酸钙的体外可控降解规律研究  

The Controlled Degradation of Calcium Polyphosphate Used in Bone Tissue Engineering

作　　者：汪前彬[1] 王启光[2] 宋巍[2] 侯旭 余喜讯[2] 万昌秀[2] 

机构地区：[1]四川大学高分子科学与工程学院,成都610065 [2]四川大学材料科学与工程学院,成都610065

出　　处：《北京生物医学工程》2010年第1期1-5,共5页Beijing Biomedical Engineering

基　　金：国家自然科学基金(30870614;30870616)资助

摘　　要：为研究骨组织工程支架材料聚磷酸钙的体外降解机理和可控降解规律,本文通过分别控制保温时间和烧结温度得到不同工艺条件的聚磷酸钙材料样品,采用X射线衍射(XRD)表征不同制备工艺材料的物象结构。以三羟甲基氨基甲烷(TRIS)氯化氢缓冲溶液为降解介质,通过失重法、钼蓝分光光度法分析材料的降解性能。用扫描电镜(SEM)观察材料在降解前后的表面形貌,并建立数学模型来描述材料的降解速率和制备工艺的内在关系。结果表明,同等保温时间下,烧结温度越高,降解速度越快,而同等烧结温度下,保温时间在3～7h之间,保温5h的材料显示了较好的降解性;数学模型得出降解液中磷酸根浓度(y)和时间(t)的关系为y=a(1-e-bt)。To investigate the degradation mechanism and controlling degradation behavior of calcium polyphosphate （CPP） for bone tissue engineering. In this paper, calcium polyphosphate were fabricated by controlling calcining time and sintering temperature. X-ray diffraction （XRD） was used to characterize the crystallographic structure of CPP. Degradation studies were performed in tris buffer solution. Each type of CPP before and after degradation was observed by scanning electron microscope （ SEM）. The degradation kinetics of polyphosphate was analyzed by establishing the mathematical model referring to the chemical reaction kinetics. The result indicated that degradation rate of CPP increased with sintering temperature and the scaffold with calcining 5 hours, during from 3hrs to 7hrs, showed the fast degradability. The mathematical modelling showed the relationship between phosphate concentration and time was y = a （ 1 - e^-bt ）.

关 键 词：聚磷酸钙 可控降解 工艺条件 数学模型 

分 类 号：R318.08[医药卫生—生物医学工程]