我国家蚕基因组的最新研究——对家蚕基因组精细图和40个蚕类基因组遗传变异图的解读  

The Latest Research Progress on Domesticated Silkworm Genome in China——The Reading of Fine Genome Map of Domesticated Silkworm and 40 Genetic Variation Maps of Domesticated and Wild Silkworms

作　　者：秦俭[1] 袁联伟[1] 

机构地区：[1]西南大学蚕学与系统生物学研究所,重庆400716

出　　处：《蚕业科学》2010年第1期115-119,共5页ACTA SERICOLOGICA SINICA

摘　　要：2008年12月,西南大学家蚕基因组研究团队宣布了世界上第1张家蚕基因组精细图谱的诞生。家蚕基因组精细图和2003年发布的家蚕基因组框架图相比,具有基因覆盖度高、基因组组装更加完整、基因鉴定更加准确等特点。2009年,该研究团队在家蚕基因组精细图的基础上,选取具有代表性的29个家蚕突变品系和11个不同地理来源的中国野桑蚕品系进行了全基因组重测序与序列比较分析,共获得了29个家蚕突变品系和11个中国野桑蚕地理品系的全基因组序列,绘制完成了世界上第1张基因组水平上的蚕类单碱基遗传变异图谱,同时还发现了驯化对家蚕生物学性状影响的基因组印记,从全基因组水平上揭示了家蚕的起源进化。2009年8月,《Science》杂志发表了西南大学的研究论文"40个蚕类基因组的重测序揭示了家蚕的驯化事件及驯化相关基因",标志着家蚕基因组计划进入一个新的历史阶段。In December 2008,the silkworm genome research team of Southwest University of China announced that the first fine genome map of domesticated silkworm（Bombyx mori） was completed in the world.Compared to the draft genome sequences released in 2003,the fine map is characterized by its deeper gene coverage,more complete genome assembly,and more accurate genetic identification etc.In 2009,based on the fine genome map of domesticated silkworm,this research team selected 29 representative domesticated silkworm strains and 11 wild silkworm strains from various geographic locations in China for re-sequencing and sequence comparative analyses.As a result,the whole genome sequences of 29 mutant strains of domesticated silkworm and 11 geographic strains of Bombyx mandarina M.were obtained.And the first genome-wide single-base genetic variation map of silkworm was generated.Meanwhile,genomic imprints relevant to the influence of domestication on silkworm biological characters were discovered,revealing important origination and evolutionary events of silkworm on genome-wide level.In August 2009,the report titled ＂Complete Resequencing of 40 Genomes Reveals Domestication Events and Genes in Silkworm（Bombyx）＂ of Southwest University was published in Science,signaling that the Silkworm Genome Project has entered a new historical phase.

关 键 词：家蚕基因组 精细图 遗传变异图 

分 类 号：S881[农业科学—特种经济动物饲养]