5-脂氧合酶在子宫内膜异位症中的表达及与血管生成的关系  

The expression of 5-LOX in endometriosis and the relationship with angionesis

作　　者：孙平平[1] 张怡[1] 宋玉莹[1] 

机构地区：[1]中南大学湘雅医院妇产科,长沙410008

出　　处：《中国医师杂志》2010年第1期71-73,共3页Journal of Chinese Physician

摘　　要：目的探讨5-脂氧合酶（5-LOX）在子宫内膜异位症（EMs）组织中的表达情况，分析5-LOX与EMs血管生成的关系。方法采用免疫组织SABC法检测32例EMs患者在位内膜和异位内膜组织中5-LOX、VEGF的表达和MVD值，并与25例正常子宫内膜进行比较。结果5-LOX、VEGF的表达及MVD值在异位内膜组高于在位内膜组和对照组（P〈0．05），三者在在位内膜组高于对照组（P〈0．05）。在异位内膜组中，5-LOX、VEGF的表达和MVD值在Ⅲ/Ⅳ期均高于Ⅰ/Ⅱ期（P〈0．05）；5-LOX、VEGF的表达及MVD值与病情严重程度呈正相关（P〈0．05）。在异位内膜组和在位内膜组中，5-LOX与VEGF的表达、MVD值均呈正相关（P〈0．05）。结论5-LOX在EMs组织中的高表达可能与EMs的发病有关，并可通过上调VEGF的表达促进EMs的新生血管的形成。Objective To investigate the expression of 5-1ipoxygenase （5-LOX） in endometriosis and analyze the relationship of 5-LOX and angionesis in endometriosis. Methods Immunochemical method was used to determine the expression of 5-LOX, VEGF, and the value of MVD in ectopic endometrium （ ectopic group） and eutopic endometrium （eutopic group） of 32 patients with EMs and in eutopic endometrium （control group） of 25 patients without EMs. Result The expressions of 5-LOX and VEGF and the value of MVD in ectopic groups were 0.43 ±0. 09,0. 39 ±0. 07 and 0.40 ±0. 09, respectively, which were higher than that of eutopic group and control group. The expressions of 5-LOX and VEGF and the value of MVD in eutopic group were 0. 35 ±0. 08, 0. 30 ±0. 06 and 0. 33 ± 0. 08, respectively, which were higher than that of control group （ P 〈 0. 05 ）. In ectopic group, the expressions of 5-LOX and VEGF, and the value of MVD in stage Ⅲ/Ⅳ, were much higher than that of stage Ⅰ/Ⅱ （ P 〈 0. 05） ; the expressions of 5-LOX and VEGF and the value of MVD were related to the severe of endometriosis through Spearman correlation analysis. The expressions of 5-LOX were shown to be significantly related to the expressions of VEGF and the value of MVD in ectopic and eutopic groups （ P 〈 0. 05）. Conclusion There is a high expression of 5-LOX in endometriosis, suggesting that 5-LOX may be participate in the pathogenesis of endometriosis. 5-LOX may promote angiogenesis of EMs through up - regulating the expression of VEGF.

关 键 词：花生四烯酸盐5-脂氧合酶/代谢 子宫内膜异位症/代谢 新生血管化 病理性 血管内皮生长因子类/代谢 毛细血管 

分 类 号：R711.71[医药卫生—妇产科学] R285.5[医药卫生—临床医学]