药源性肝损害185例临床分析  

Drug-induced hepatic lesions:clinical analysis of 185 cases

作　　者：邱雄[1] 唐力[2] 周祥慧[3] 

机构地区：[1]雅安职业技术学院附属医院消化内科,四川雅安625000 [2]双流县第一人民医院内科,四川双流610200 [3]雅安市人民医院,四川雅安625000

出　　处：《四川医学》2010年第2期207-208,共2页Sichuan Medical Journal

摘　　要：目的探讨药物性肝损害的临床特点及其发生规律。方法对雅安市人民医院1999年1月-2009年10月185例药物性肝损害患者的临床资料进行回顾性分析。结果引起肝损害的药物中抗肿瘤药及免疫抑制剂占35．10％，抗结核药占21．00％，抗生素占20．00％，中草药占18．30％；肝细胞损伤型占67．50％，胆汁淤积型占14．50％，混合型占17．80％。结论药物性肝损害的临床特点与病毒性肝炎相似，并无特异性。引起肝损害的药物较多，应引起重视。Objective To discuss the clinical features and the general pattern of drug-induced hepatic lesions. Methods The clinical data of 185 drug-induced hepatic lesion eases collected from Jan 1999 to Oct 2009 in the People＇s Hospital of Yaan were analyzed retrospectively. Results Of the 185eases,35.10% were induced by anti-neoplastic agent and immunosuppressive agents,21.00 % by anti-tuberculosis agent,20% were induced by antibiotios, 18.30 % were induced by Chinese herbal medicines;67.50 % were hepatocellular damage type, 14.50 % eholestatic damage type andl7.80 % damage of mixed type damage. Condnsion Hepatic lesions resemble viral hepatitis and were of no specificity in clinical features ;various drugs can lead to hepatic lesions and to which clinic should attach great importance.

关 键 词：药物性肝损害 回顾性分析 临床特点 

分 类 号：R595.3[医药卫生—内科学]