胰岛素样生长因子-Ⅰ、Ⅱ水平与子前期相关性研究  

Study on the correlation between the levels of IGF-Ⅰ and Ⅱ and pre-eclampsia

作　　者：丁华[1] 黄丽萍[1] 刘和录[1] 张荣贵[1] 陈望[1] 郭海香[1] 

机构地区：[1]广州医学院附属深圳沙井医院,广东省深圳市518104

出　　处：《中华实用诊断与治疗杂志》2010年第3期241-243,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：深圳市宝安区科研立项课题(2008202)

摘　　要：目的:探讨胰岛素样生长因子Ⅰ、Ⅱ水平在子前期发病机制及诊断中的作用。方法:选择38例子前期孕妇为子前期组(其中轻度18例,重度20例),30例正常妊娠晚期孕妇为对照组,应用ELISA检测对照组和轻、重度子前期组孕妇静脉血、新生儿脐血及羊水中胰岛素样生长因子-Ⅰ、Ⅱ的含量,分析与子前期发病相关性。结果:(1)孕妇血、新生儿脐血及羊水中胰岛素样生长因子-Ⅰ含量在重度子前期组明显低于轻度子前期组(P<0.01),轻度子前期组明显低于对照组(P<0.01)。(2)孕妇血及羊水中胰岛素样生长因子-Ⅱ含量在重度子前期组明显低于轻度子前期组(P<0.01),轻度子前期组明显低于对照组(P<0.01);新生儿脐血中胰岛素样生长因子-Ⅱ含量在重度子前期组明显高于轻度子前期组(P<0.01),轻度子前期组明显高于对照组(P<0.01)。(3)子前期孕妇血及羊水中胰岛素样生长因子-Ⅰ、Ⅱ的水平与病情轻重呈正相关,新生儿脐血,胰岛素样生长因子-Ⅰ水平与病情轻重呈正相关,胰岛素样生长因子-Ⅱ水平与病情轻重呈负相关。结论:孕妇血、新生儿脐血及羊水中胰岛素样生长因子-Ⅰ、Ⅱ水平变化可作为预测和诊断子前期发病和疾病程度的一个指标。Objective To investigate the roles of the IGF-Ⅰ and Ⅱ levels in the pathogenesis and diagnosis of pre eclampsia. Methods Thirty-eight cases of pre-eclampsia were chosen as pre eclampsia group （18 cases mild and 20 cases severe）. Another 30 normal late pregnant women were as controls. ELISA was used to detect IGF-Ⅰ and Ⅱ contents in the maternal blood, umbilical blood and amniotic fluid in control group and pre eclampsia group. The correlation with pathogenesis of pre-eclampsia was analyzed. Results （1） IGF-Ⅰ contents in the maternal blood, umbilical blood and amniotic fluid levels were significantly lower in severe pre-eclampsia group than those in the mild pre-eclampsia group （P〈0. 01）, and were lower in mild pre-eclampsia group than those in control group （P〈0.01）. （2） IGF-Ⅱ contents in the maternal blood and amniotic fluid were significantly lower in severe pre-eclampsia group than those in mild pre-eclampsia group （P〈0.01）, and were lower in mild pre-eclampsia group than those in control group （P〈0.01）. IGF Ⅱ content in umbilical blood was significantly higher in severe pre-eclampsia group than that in mild pre-eclampsia group （P〈0.01）, and was significantly higher in mild pre eclampsia group than that in control group （P〈0.01）. （3） IGF-Ⅰ and Ⅱ levels in maternal blood and amniotic fluid in pre-eclampsia were positively correlated with the severity of illness, while IGF-Ⅰ level in umbilical blood was positively correlated with the severity of illness, and IGF-Ⅱ level was negatively correlated with the severity of the disease. Conclusion The IGF-Ⅰ and Ⅱ levels in maternal blood, umbilical blood and amniotic fluid can be used to predict and diagnose pre-eclampsia and its degree.

关 键 词：子癎前期 孕妇血 脐血 羊水 胰岛素样生长因子Ⅰ 胰岛素样生长因子Ⅱ 

分 类 号：R714.245[医药卫生—妇产科学]