青春期儿童血清瘦素脂联素与血脂水平的配对研究  

Matched Pair Study About Levels of Serum Leptin,Adiponectin and Blood Fat Among Adolescents

作　　者：王会贞[1] 陈新岭[1,2] 娄晓民[1] 谭贵清[3] 陈姜[1] 胡巧云[1] 

机构地区：[1]郑州大学公共卫生学院,河南450001 [2]焦作卫生学校预防医学教研室 [3]新乡市教育局中小学卫生保健站

出　　处：《中国学校卫生》2010年第2期190-191,共2页Chinese Journal of School Health

基　　金：河南省教育厅自然科学研究项目(编号:2006320028)

摘　　要：目的探讨青春期儿童血清瘦素(LEP)、脂联素(ADIPO)与血脂的关系,为心血管疾病的早期预防提供线索。方法选取13～14岁肥胖和体重正常儿童共73对,用放射免疫法测血清LEP,用酶联免疫法测血清ADIPO,用酶比色法测三酰甘油(TG)及总胆固醇(TC),用沉淀法测高密度脂蛋白(HDL)和低密度脂蛋白(LDL),进行配对分析。结果肥胖组儿童血清LEP(24.011±6.831)μg/L,TG(1.574±0.889)mmol/L水平高于对照组(12.542±6.565)μg/L,(0.913±0.362)mmol/L(P值均=0.000);ADIPO(4.074±2.493)μg/mL,HDL(1.115±0.256)mmol/L水平低于对照组(5.526±3.194)μg/mL,(1.404±0.331)mmol/L(P值均<0.01)。女童血清LEP与LDL呈正相关(r=0.246,P=0.043),与HDL呈负相关(r=-0.438,P=0.000);男童血清LEP与TG(r=0.518,P=0.000),TC(r=0.284,P=0.012)均呈正相关,与HDL呈负相关(r=-0.353,P=0.002),ADIPO与HDL呈正相关(r=0.253,P=0.025)。结论青春期肥胖儿童存在瘦素、脂联素和血脂代谢紊乱,瘦素较脂联素与血脂有明显的相关性。Objective To explore relationship among leptin{ LEP）, adiponectin { ADIPO} and blood fat among adolescents, and to provide clue for early prevention on cardiovascular disease. Methods 73 pairs of obesity and normal adolescents were selected from children aged 13 - 14 years. Their LEP level in serum was measured by radio-immunity method, ADIPO was measured with ELISA, TG and TC were measured by enzyme colorimetry, HDL and LDL were measured by precipitation method. Then pairs analysis was taken. Results Obesity group＇s LEP and TG levels （ 24.011 ± 6.831 μg/L, 1. 574 ± 0. 889 mmol/L ） were higher than control group （ 12. 542 ± 6. 565 μg/L, 0.913 ± 0. 362 mmol/L ） （ P = 0. 00 ） , but their ADIPO and HDL levels{4.074 ±2.493 μg/mL, 1. 115 ±0. 256 mmoL/L} were lower than control group（5. 526 ±3. 194 μg/mL, 1. 404 ±0. 331 mmol/L} { P 〈 0.01 }. Girls LEP level had positive correlation with LDL（ r = 0. 246, P = 0. 043 } , and had negtive correlation with HDL{ r = -0. 438 ,P =0. 000）. Boys LEP level showed negtive correlation with HDL（r = -0. 353, P = 0. 002） and positive correlation with TG { r = 0.518,P=0.000} and TC（r =0.284,P=0.012）, their ADIPO was positively correlated with HDL{r=0.353,P =0.025}. Conclusion There are metabolic disturbance in leptin, adiponectin and blood fat among obese adolescents. Compared with adiponeetin, LEP is more closely correlated with blood fat.

关 键 词：瘦素 血脂异常 血液化学分析 配对分析 儿童 青春期 

分 类 号：R179[医药卫生—妇幼卫生保健] R339.35[医药卫生—公共卫生与预防医学]