头顶一棵珠对脑缺血再灌注损伤大鼠的保护作用  

The protective efect of Trillium tschonoskii Maxim on focal cerehral reperfusion injury in rat

作　　者：刘红[1] 艾明仙[1] 阳辉[1] 

机构地区：[1]湖北民族学院医学院药理教研室,恩施445000

出　　处：《中药药理与临床》2009年第6期66-68,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：湖北省教育厅科研基金资助(D200729005)

摘　　要：目的:以大鼠脑缺血再灌流期间神经行为学及生化指标变化评价头顶一棵珠对脑缺血再灌注损伤的保护作用。方法:大鼠灌胃头顶一棵珠30d,采用线栓法造成大鼠局灶性脑缺血再灌流损伤模型。分别进行大鼠神经行为学评判以及脑含水量、缺血区梗死面积、脑组织超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)含量的检测。结果:头顶一棵珠可明显改善大鼠神经行为学症状,降低脑组织含水量及大脑缺血区梗死面积,明显降低大鼠脑纽织MDA含量,同时对SOD、NO的变化也有一定的改善作用。结论:头顶一棵珠对大鼠脑缺血再灌注损伤有显著的保护作用,其作用可能与抗氧化有关。Objective：To observe the potential protective efect and possible mechanism of Trillium tschonoskii Maxim to the rats during foeal cerebral ischemia-repefusion injury.Methods：Transient middle cerebral artery（MCA）occlusion was induced as described by Longa,After 2 hours of cerebral ischemia and 22 hours of reperfusion,scores of neurological deftcit were observed and the cerebral infarction size was measured by 2,3,5-triphenytetrazolium chloride（TTC） staining technique.Nitric oxide（NO）,superoxide dismutase（SOD） and malondialdehyde（MDA） levels were also observed by chemical methods.Results：Compared with MCAO model group,scores of neurological deficit and infarct volume were lower significantly in the groups treated with Trillium tschonoskii Maxim,and the nitric oxide（NO）,malondialdehyde（MDA） levels were found decreased.Conclusion：The Trillium tschonoskii Maxim could protect brain damage after focal cerebral ischemia reperfusion in vivo,and the possible mechanism seemed to be that it could release the injury of fat over oxidizing.

关 键 词：头顶一棵珠 脑缺血 缺血再灌注损伤 

分 类 号：R285.5[医药卫生—中药学]