山东地区丙型肝炎病毒基因型及相关因素分析  

Genotypes and related factors of hepatitis C virus in patients infected with HCV in the Shandong area

作　　者：徐皖苏[1] 刘靓雯[1] 秦晓华[1] 刘宗清[1] 

机构地区：[1]济南市传染病医院中心实验室,济南250021

出　　处：《山东大学学报（医学版）》2010年第2期140-141,145,共3页Journal of Shandong University:Health Sciences

摘　　要：目的探索山东地区丙型肝炎病毒(HCV)基因分型及其相关关系。方法采用基因芯片技术检出了448例HCV感染者的血清HCV基因型,同时检测了其中388例血清HCV RNA的含量,并对HCV基因型与HCV感染者的性别、年龄和HCV RNA含量进行了相关性分析。结果检测到4种基因亚型(1a、1b、2a、3b),呈8种组合;其中1b和2a亚型多见,分别占61.2%(274例)和32.8%(147例)。Logistic多因素分析表明,基因1b型与HCV高病毒载量独立相关。结论山东地区HCV基因分型以1b型为主,且与HCV高病毒载量相关。Objective To explore the distribution and related factors of hepatitis C virus （HCV） genotypes. Methods HCV genotypes were detected using gene chip assay in 448 patients who were infected with HCV. HCV RNA levels were quantified by real-time PCR in 388/448 patients. The correlation between HCV genotypes and each variable （including gender, age, the HCV level） was analyzed. Results 4 HCV genotypes （ 1a, 1b, 2a and 3b） and 4 mixed genotypes （ 1b ＋ 2a, 1 a ＋ 1 b, 1 a ＋ lb ＋ 2a, 1b ＋ 3b） were found; of these lb and 2a were the more common genotypes, accounting for 61.2% and 32.8% respectively. Logistic regression analysis indicated that genotype lb independently correlated with high serum HCV RNA level. Conclusion HCV genotype 1 b predominates in patients with HCV infection in the Shandong area, correlating with high serum HCV RNA level.

关 键 词：肝炎病毒 丙型 核糖核酸 丙型肝炎病毒 基因型 

分 类 号：R512.63[医药卫生—内科学]