复方蒿甲醚片联合伯氨喹治疗恶性疟临床疗效观察  

OBSERVATION OF CURATIVE EFFECT OF FALCIPARUM MALARIA TREATED WITH ARTEMETHER TABLETS AND PRIMAQUINE

作　　者：李文俊[1] 李晓灵[1] 

机构地区：[1]成都市传染病医院,成都610061

出　　处：《现代预防医学》2010年第5期973-974,共2页Modern Preventive Medicine

摘　　要：[目的]探讨复方蒿甲醚片联合伯氨喹治疗恶性疟的临床疗效。[方法]将在安哥拉罗安达总医院收治的恶性疟174例患者,随机分成两组,治疗组88例,口服复方蒿甲醚片,每天80mg,首剂加倍,连用7d后,接着服用磷酸伯氨喹片39.6mg(相当于伯氨喹22.5mg),连用4d;对照组86例,单用复方蒿甲醚片治疗,所用剂量和疗程同治疗组。[结果]治疗组和对照组病例的治愈率为98.86%和94.18%;平均退热时间为(42.4±9.8)h和(45.1±13.2)h;复燃率为5.68%和29.07%。[结论]蒿甲醚片联合伯氨喹治疗恶性疟的疗效显著,作用迅速,复燃率明显低于对照组。[Objective] To explore the efficacy in falciparum malaria cases with Artemether and Primaquine.[Methods] Randomization and comparison methods were used in 174 falciparum malaria cases who were taken in and given treatment in hospital GERAL DE LUANDA of Angola.Among them 88 cases were treated with Artemether（80mg,orally,qd＊7d） then with Primaquine（22.5mg orally,qd＊4d）;86 cases received single Artemether were taken as controls.All of them were conducted follow-up after treatment.[Results] In combined group and control group,clinical cure rates were 98.86% and 94.18%,the mean fever clearance time were（42.4±9.8） hours and（45.1±13.2） hours,relapse rate was 5.68% and 29.07% respectively.[Conclusion] Combined methods show high efficacy and quicker effect in treatment of plasmodium falciparum,and are more effective in reducing relapse rate of malaria.

关 键 词：恶性疟 蒿甲醚片 伯氨奎 诊断 治疗 

分 类 号：R531.3[医药卫生—内科学]