TP/PD-ECGF和VEGF在骨肉瘤中的表达与血管生成的关系  

Relationship between TP/PD-ECGF and VEGF expression and angiogenesis in osteosarcoma

作　　者：刘守正[1] 宋玉鑫[2] 康龙[1] 张敬贤[1] 殷均山[1] 

机构地区：[1]沭阳县人民医院骨一科,江苏沭阳223600 [2]甘肃省人民医院骨科,甘肃兰州730000

出　　处：《现代医药卫生》2010年第3期343-345,共3页Journal of Modern Medicine & Health

摘　　要：目的:研究胸苷磷酸化酶/血小板衍化内皮细胞生长因子(TP/PD-ECGF)和血管内皮生长因子(VEGF)在骨肉瘤组织中的表达与微血管密度(MVD)的关系及其临床病理意义。方法:应用免疫组织化学SP法,检测54例骨肉瘤组织中TP/PD-ECGF与VEGF的表达,CD34单克隆抗体标记血管内皮细胞计数骨肉瘤MVD。结果:TP/PD-ECGF表达程度与MVD呈正相关;TP/PD-ECGF和VEGF在骨肉瘤中的阳性表达呈正相关;TP/PD-ECGF和VEGF在骨肉瘤中的表达与骨肉瘤临床病理因素无统计学意义,但与肺转移显著相关。结论:TP/PD-ECGF与VEGF是骨肉瘤血管形成的重要调节因子,并与骨肉瘤肺转移密切相关,可联合作为评价骨肉瘤患者预后的一项客观指标。Objective：To investigate the relationship between angiogenesis and thymidine phsphorylase/platelet-derived endothelial cell growth factor （TP/PD-ECGF） and vascular endothelial growth factor （VEGF）expression in osteosarcoma and their clinicopathological significance.Methods ：The expression of TP/PD-ECGF and VEGF was evaluated by immunohistochemical staining of tumor speciments from 54 patients with osteosarcoma. The microvessel density（MVD） was assessed by immunostaining with CD34 in the most neovascularized area（hot spots）.Results：The close correlation was found between TP/PD-ECGF expression and microvessel density.The close correlation was found between TP/PD-ECGF and VEGF expression.TP/PD-ECGF and VEGF expression was remarkably correlated with lung metastasis in osteosarcoma.In contrast,no association was found between TP/PD-ECGF expression and gender, age,size and location of tumor, osteosarcoma classification,as well VEGF.Conclusion：TP/PD-ECGF and VEGF are two of important angiogenic factors and maybe play a role in lung metastasis in human osteosarcoma.

关 键 词：骨肉瘤 胸苷磷酸化酶 血小板衍化内皮细胞生长因子 血管内皮生长因子 微血管密度 肺转移 

分 类 号：R6[医药卫生—外科学]