益气化痰通络方对股动脉粥样硬化和超敏C反应蛋白水平的影响  

Effects of "Yiqi Huatan Tongluo Decoction" on femoral artery atherosclerosis and the level of hs-CRP

作　　者：陈敬贤[1] 陈咸川[2] 

机构地区：[1]上海交通大学医学院附属瑞金医院中医科,上海200025 [2]上海中医药大学附属岳阳中西医结合医院老年科,上海200437

出　　处：《上海中医药杂志》2010年第2期40-42,共3页Shanghai Journal of Traditional Chinese Medicine

摘　　要：目的观察益气化痰通络方对股动脉硬化患者股动脉内-中膜厚度(IMT)和超敏C反应蛋白(hs-CRP)的影响。方法将58例股动脉粥样硬化患者随机分为治疗组和对照组,对照组予降脂药辛伐他汀40mg/d,治疗组在对照组基础上加用益气化痰通络方(黄芪、当归、地龙、桑椹、丹参、茶树根、泽泻、石菖蒲等组成)。疗程均为12周。结果治疗组和对照组均可有效降低血清胆固醇、低密度脂蛋白浓度(P<0.05,P<0.01)。治疗组股动脉IMT均值较治疗前明显降低(P<0.01),而对照组无明显改变,两组间差异有显著性(P<0.01);治疗组和对照组血清hs-CRP均明显低于治疗前(P<0.01,P<0.05),且治疗组明显低于对照组(P<0.05)。结论益气活血化痰通络方可消减股动脉粥样硬化,对IMT和hs-CRP有明显调节作用。Objective To observe the effect of ＂Yiqi Huatan Tongluo Decoction＂ on femoral artery＇ s intima medial thickness（IMT） and the level of hs-CRP. Methods Fifty-eight patients with femoral artery atherosclerosis were randomized into two groups： control group was given Simvastatin（40 mg/d） and treatment group was given ＂Yiqi Huatan Tongluo Decoction＂, both with a course of 12 weeks. Results After treatment, serum total cholesterol, low density lipid was reduced in both treatment group and control group（P 〈0.05, P 〈0.01 ） ; the femoral artery＇s IMT of treatment group was thinner（ P 〈0.01 ）, while it remained unchanged in control group, with a significant difference between the two groups （ P 〈 0.01 ） ; the hs-CRP levels of both two groups were lowered （ P 〈 0.01, P 〈0.05 ）, with more significant lowering in treatment group than in control group（P 〈0.05 ）. Conclusion ＂Yiqi Huatan Tongluo Decoction＂ can delay the progression of femoral artery atherosclerosis and regulate the IMT and hs-CRP.

关 键 词：益气化痰通络方 股动脉粥样硬化 股动脉内-中膜厚度 超敏C反应蛋白 

分 类 号：R285.5[医药卫生—中药学] R743[医药卫生—中医学]