降压通脉方对自发性高血压大鼠血压及左心室肥厚的影响  

Effects of Jiangya Tongmai Formula on blood pressure and left ventricular hypertrophy of spontaneous hypertensive rats

作　　者：王亚红[1] 肖文君[2] 罗斯琼 王琛[1] 韩俊阁[1] 尚涛[1] 王刚[1] 郭维琴[1] 王硕仁[1] 

机构地区：[1]北京中医药大学东直门医院中医内科学教育部重点实验室,北京100700 [2]北京市崇文区第一人民医院,北京100075 [3]北京市东城区社区卫生服务中心,北京100011

出　　处：《中华中医药杂志》2010年第3期369-371,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金资助项目(No.30572460)~~

摘　　要：目的:探讨降压通脉方控制血压、逆转高血压左心室肥厚的作用。方法:以自发性高血压大鼠(SHR)为高血压及高血压左心室肥厚模型,随机分为降压通脉方组、卡托普利组、空白对照组;并以WKY大鼠为正常对照组。检测大鼠尾动脉收缩压(SBP)、大鼠左室质量(LV)、左心室质量指数(LVMI)、左室壁相对厚度。结果:与模型组比较,中药组于药后第4周出现血压下降,降压效果于第14周达到与西药相比无明显差异。模型组、中药组、西药组LVMI较正常组明显升高,提示左室肥厚形成,中药组、西药组左室壁相对厚度较模型组室壁薄,提示降压通脉方有逆转左室肥厚的作用。结论:降压通脉方可有效地降低SHR血压,有一定逆转SHR左心室肥厚的作用。Objective： To study the effect of Jiangya Tongmai Formula on blood pressure and left ventricular hypertrophy （ LVH ） of spontaneous hypertensive rats（SHR）. Methods： Taking SHR for animal model of hypertension and LVH, divided then into 4 groups at random： distilled water group, Jiangya Tongmai Formula group, Captopril group, control group and WKY rats were used as a normal group. The SBP of arteria caudilis, left ventricular mass index （LVMI）, the weigh of LV, and trans-diameter of cardiomyocyte （TDM） on sections of the left ventricular mid- free wall were measured. Results： Compared with model group, the blood pressure in Jiangya Tongmai Formula group decreased after 4 weeks treatment, and the effect of Jiangya Tongmai Formula was the same as the Captopril on the blood pressure after 14 weeks treatment. Compared with the normal group, the LVMI increased obviously in model group, Jiangya Tomgmai Formula group and Captopril group. Compared with model group, the TDM in Jiangya Tongmai Formula group and Captopril group decreased. Conclusion： Jiangya Tongmai Formula can control the blood pressure, reverse left ventricular hypertrophy.

关 键 词：高血压 左心室肥厚 动物实验 降压通脉方 

分 类 号：R285.5[医药卫生—中药学]