中药脐部贴敷对肝硬化内毒血症的影响  

Clinical research of effect of umbilical Chinese materia medica paste on endotoxemia of cirrhosis patients

作　　者：施维群[1] 倪伟[1] 

机构地区：[1]浙江中医药大学附属第二医院,杭州310005

出　　处：《中华中医药杂志》2010年第3期452-455,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：浙江省医药科技卫生项目(No.2006A91)~~

摘　　要：目的:观察中药脐部贴敷剂结合透皮促进剂治疗肝硬化内毒素血症的疗效及安全性。方法:根据鲎血细胞基质显色试验,将80例内毒素血症阳性的肝硬化患者,按随机数字表法分为对照组40例和治疗组40例。两组在常规治疗基础上,治疗组加用中药脐部贴敷剂,两组疗程均为1个月。3个疗程结束后对患者的临床症状、血浆内毒素、血浆氨、血清补体C3测定,肝功能、凝血功能及血常规等指标进行统计分析和疗效比照。结果:治疗后,治疗组和对照组内毒素均显著降低(P<0.05,P<0.01),组间对照差异有显著性意义(P<0.05);两组总胆红素(TBIL)值均显著降低(P<0.01),组间对照差异有非常显著性意义(P<0.01)。症状积分下降程度治疗组较对照组下降明显,两组间差异有非常显著性意义(P<0.01)。结论:本中药脐部贴敷剂可显著地降低肝硬化内毒素血症,减轻患者的临床症状,无明显毒副作用,作为治疗肝硬化内毒素血症的一种新方法值得进一步研究。Objective： To investigate the efficacy and security of umbilical Chinese materia medica paste on the endotoxemia of cirrhosis patients. Methods： Based on the TAL blood cell matrix color test, 80 cases of cirrhosis patients with endotoxemia positive were divided into two groups by randomly number： 40 in the received regular treatment period for both groups was one month. The clinical symptoms was given to the level of treatments; Additionally, Chinese materia medica paste on umbilicus was given to the treatment group, the endotoxin, ammonia and complement component 3 in serum, cruor function, liver function, and blood routine test were statistical analysised and efficacy compared in both groups after treatment. Results： After treatment, endotoxin decreased significantly in the treatment group and the control group （P〈0.01, P〈0.05）, there was significant difference between the two groups （P〈0.05）; TBIL decreased significantly in both groups （P〈0.01）, there was very significant difference between the two groups （P〈0.01）. The score of symptoms decreased in treatment group was more significantly than that in the control group, there was very significant difference between the two groups （P〈0.01）. Conclusion： The Chinese materia medica paste on umbilicus could significantly decreased the endotoxemia and relieved the symptoms of cirrhosis patients, there was not significant side effect. It＇s worth to further research that it could be a new method for the treatment of cirrhosis endotoxemia.

关 键 词：中药 外治 脐 肝硬化 内毒素血症 

分 类 号：R244.9[医药卫生—针灸推拿学]