相转移催化下2,6-二氯吡啶的羟基化反应  

Phase-transfer catalytic hydroxylation of 2,6-dichloropyridine

作　　者：马恩忠[1] 田甜[2] 

机构地区：[1]天津师范大学化学与生命科学学院,天津300387 [2]南开大学滨海学院环境科学系,天津300270

出　　处：《天津师范大学学报（自然科学版）》2010年第1期55-56,80,共3页Journal of Tianjin Normal University：Natural Science Edition

摘　　要：以2,6-二氯吡啶与氢氧化钾为原料,选用不同的溶剂和催化剂,生成2-羟基-6-氯吡啶的反应,分析了溶剂和催化剂对该反应的影响,得出用正丁醚作为溶剂,四丁基溴化铵作为相转移催化剂为最佳的结论,产品收率为86.4%,该化合物经元素分析和红外光谱得到确证.The reactions of 2,6-dichloropyridine and potassium hydroxide,which resulted in the formation of the corresponding product 2-hydroxy-6-chloropyridine with different solvents and catalysts were investigated.The effects of solvents and catalysts on the outcome of the reaction were studied.Butyl ether is introduced as a solvent,tetrabutyl ammonium bromide an excellent catalytic system for the synthesis of 2-hydroxy-6-chloropyridine,and this method gave 2-hydroxy-6-chloropyridine in 86.4% yield.This compound was comfirmed by IR and elemental analysis.

关 键 词：2 6-二氯吡啶 羟基化 相转移催化 反应活性 

分 类 号：Q968.1[生物学—昆虫学]