微波辐射合成对乙酰氨基酚的研究  

Microwave-assisted synthesis of acetaminophen

作　　者：邵艳东[1] 李永红[1] 俞应华[1] 赵启鹏[1] 韦佳[1] 

机构地区：[1]滁州学院化学与生命科学系,安徽滁州239012

出　　处：《应用化工》2010年第2期192-194,共3页Applied Chemical Industry

基　　金：安徽省应用化学省级重点学科建设项目资助(200802187C);滁州学院大学生科研项目(2009xs037)

摘　　要：以对氨基苯酚和乙酸酐为原料,以锌粉为抗氧化剂,以活性炭为脱色剂,以稀乙酸为反应介质,采用微波辐射技术合成对乙酰氨基酚。探索了不同反应条件对产率的影响。实验表明,当n(对氨基酚)∶n(乙酸酐)为1∶1.3,反应介质稀乙酸体积浓度为4%,微波辐射功率为500 W,反应时间为17 m in,反应温度为105℃时,产率可达82.1%。The p-aminophenol and acetic anhydride were used to synthesize acetaminophen under microwave irradiation. The reaction was carried out in the solvent of diluted acetic acid with zinc as the anti-oxidants and activated carbon as decolorizing agent. The effect of various reaction conditions on yield was investigated, and experimental results showed that when n （p-amino phenol） ： n （acetic anhydride） is 1：1.3 ,the volume concentration of dilute acetic acid is 4% ,microwave radiation power is 500 W, the reaction time is 17 min,the reaction temperature is 105℃ ,the yield can be up to 82.1%.

关 键 词：对乙酰氨基酚 微波辐射 合成 

分 类 号：TQ463.4[化学工程—制药化工]