乙醛脱氢酶2基因多态性与心脑血管疾病  

Aldehyde Dehydrogenase 2 Gene Polymorphism and Cardio-cerebrovascular Diseases

作　　者：屈启才[1] 黄青青[1] 

机构地区：[1]昆明医学院第二附属医院麻醉科,昆明650101

出　　处：《医学综述》2010年第4期487-489,共3页Medical Recapitulate

基　　金：云南省科技计划项目(2009CD)

摘　　要：乙醛脱氢酶2(ALDH2)是存在于线粒体内的一种醛类氧化酶,是体内重要的氧化应激分子。ALDH2野生型可抑制心肌细胞的凋亡,降低心功能不全的发生率。ALDH2突变型是心肌梗死的独立危险因素,但可以降低高血压的发生率。此外,ALDH2野生型不依赖醛类途径增加了脑梗死的发病率。Aldehyde dehydrogenase 2（ALDH2）is an oxidizing enzyme of the aldehydes in the mitochondrion,and it is an important oxidative stressful molecule in body.The wild type ALDH2 can inhibit the apoptosis of the myocardium,reduce incidence of the cardiac insufficiency.The mutant ALDH2 is an independent risk factor of the myocardial infarction,but it can reduce incidence of the hypertension.Besides,the wild type ALDH2 can increase the the incidence rate of the cerebral infarction independent of the aldehydes way.

关 键 词：乙醛脱氢酶2 心肌梗死 动脉粥样硬化 腔隙性脑梗死 高血压 

分 类 号：R543[医药卫生—心血管疾病]