植物黄酮类治疗糖尿病药理机制的研究进展  

Research Progresses in Pharmaceutical Mechanisms of Treating Diabetes Mellitus by Plant Flavonoids

作　　者：王勇[1] 赵海燕[1] 

机构地区：[1]北方民族大学生物科学与工程学院,银川750021

出　　处：《医学综述》2010年第4期612-615,共4页Medical Recapitulate

基　　金：国家教育部留学回国人员科研启动基金(2005年);国家民委生态系统模型及应用重点开放实验室科研项目(2008SY06)

摘　　要：黄酮类化合物是高等植物中一类重要的次生代谢产物。近年来研究发现,很多植物黄酮类化合物对糖尿病及并发症有明显的防治作用,对其药理机制也有一些报道。现对植物黄酮类保护胰岛β细胞、抑制α-葡萄糖苷酶活性、提高机体对胰岛素的敏感性、促进外周组织对糖的利用、激活过氧化物酶体增殖物激活受体等药理机制的最新研究进展进行综述,以期为抗糖尿病新药的开发提供理论指导。Flavonoids are a class of important secondary metabolites of higher plants.It has been found recently that many plant flavonoids can be applicated in treating diabetes and its complications and some of their pharmaceutical mechanisms have also been reported.This paper reviewsed the latest research progresses in pharmaceutical effects of plant flavoniods on protecting pancreatic β cells,inhibiting α-glucosidase activity,increasing insulin sensitivity,promoting glucose utilization by peripheral tissue and activating peroxisome proliferator-activated receptor,etc.in hoping to provide theoretical guidance for developing new anti-diabetic drugs.

关 键 词：植物黄酮 药理机制 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]