微波辐射下一锅法合成2-氨基-6-溴-4-芳基-5H-茚并[1,2-b]吡啶-3-腈衍生物  

One-Pot Synthesis of 2-Amino-6-bromo-4-(substituted phenyl)-5H-indeno[1,2-b]pyridine-3-carbonitrile Derivatives under Microwave Irradiation

作　　者：季春香[1] 薛永震 王建强[1] 殷俊[1] 崔永涛[1] 郭成[1] 

机构地区：[1]南京工业大学理学院,南京210009 [2]南京化工研究院,南京210033

出　　处：《有机化学》2010年第2期233-237,共5页Chinese Journal of Organic Chemistry

摘　　要：以芳香醛、4-溴茚酮、丙二腈和醋酸铵为原料,分别用微波辐射和传统加热法,一步法合成7种未见文献报道的2-氨基-6-溴基-4-芳基-5H-茚并[1,2-b]吡啶-3-腈衍生物.对比两种方法,在常压下微波具有反应时间短、产率较高等特点.所有化合物均经IR,1HNMR和元素分析确定.Seven new 2-amino-6-bromo-4-（substituted phenyl）-5H-indeno[1,2-b]pyridine-3-carbonitrile derivatives were synthesized by using benzaldehydes, 4-bromo-indan-1-one and malononitrile in one-pot via conventional heating and microwave irradiation techniques. By comparison of the two methods, the microwave irradiation possessed such advantages as short reaction time, high yields and so on over the conventional method under normal pressure. The structures of these compounds were characterized by IR, ^1H NMR spectra and elemental analysis.

关 键 词：4-溴茚酮 微波辐射 茚并[1 2-b]吡啶 传统加热 

分 类 号：O626.32[理学—有机化学]