拟肾上腺素药盐酸甲氧明的绿色合成  

Green Synthesis of the Adrenomimetic Drug Methoxamine Hydrochloride

作　　者：谢宇[1] 胡金刚[1] 贾杰[1] 洪小伟[1] 魏娅[1] 

机构地区：[1]南昌航空大学环境与化学工程学院,南昌330063

出　　处：《有机化学》2010年第2期282-284,共3页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.20904019);江西省自然科学基金(No.0620071);江西省教育厅科技(No.赣教技字[2007]168号);航空高校基金(No.EA200502138)资助项目

摘　　要：以对苯二酚为原料经羟基的甲基化、傅克酰基化、肟化、肟基还原、酮胺氢化5步反应合成了盐酸甲氧明,中间体和目标产物经核磁共振氢谱、红外光谱及元素分析仪确证了其化学结构,总收率为37.6%.与传统盐酸甲氧明工艺相比,该工艺反应条件温和、简便、经济、产率高及对环境友好.Methoxamine hydrochloride was synthesized from p-dihydroxybenzene by O-methylatlon, Friedel-Crafts acylation, oximation reaction, oxime reduction and keto-amine hydrogenation reactions. All intermediates and products were characterized by IR, lH NMR spectra and elemental analysis. The total yield was 37.6%. Compared to the traditional synthetic procedures of methoxamine hydrochloride, the procedures were temperate, convenient, economical, high-yielding and environment-friendly.

关 键 词：甲氧明 甲基化 肟化 还原 绿色合成 

分 类 号：TQ463.2[化学工程—制药化工]