布托啡诺对芬太尼诱发呛咳反应的临床研究  

Effect of butorphanol to depress the bucking which was induced by fentanyl

作　　者：张钧[1] 徐峰[1] 王雁娟[2] 

机构地区：[1]南京医科大学附属淮安市第一人民医院麻醉科,223200 [2]南京医科大学附属无锡市人民医院麻醉科,214000

出　　处：《重庆医学》2010年第4期432-433,共2页Chongqing medicine

摘　　要：目的研究布托啡诺对降低全麻诱导期间芬太尼引发的呛咳反应发生率的影响。方法将100例ASA(美国麻醉师协会根据患者体质状况和对手术危险性进行的分级)Ⅰ～Ⅱ级的择期手术患者随机分为两组,每组50例。Ⅰ组静脉给予生理盐水1mg,Ⅱ组静脉给予布托啡诺1mg;5min后均由左上肢静脉给予5μg/kg芬太尼,观察1min内呛咳反应发生率。结果Ⅰ组80%患者发生呛咳反应,Ⅱ组呛咳反应发生率明显降低(4%),两组比较差异有统计学意义(P<0.01)。结论静脉注射布托啡诺可以明显减轻全麻诱导期间芬太尼引发的呛咳反应。Objective To investigate the effect of butorphanol to depress the bucking which was induced by fentanyl during inductive phase of general anesthesia. Methods 100 subjects with a diagnosis of needing to accept selective operation,scaled Ⅰ～Ⅱ by ASA, were divided into two groups randomly. The first group was administrated l mg Sodium Chloride, and the second group was administrated 1 rag. 5 minutes later,both of the two groups were injected fentanyl with a dosage of 5μg/kg by way of Veins of left upper extremity. The incidence of bucking was observed in a minute. Results 80% patients suffered of bucking in the first group, while the second group＇s incidence of bucking was lower to 4% ,and there was significant difference between the two groups. Conclusion The injection of butorphanol can significantly relieve bucking caused by fentanyl during inductive phase of general anesthesia.

关 键 词：布托啡诺 芬太尼 呛咳反应 

分 类 号：R614.2[医药卫生—麻醉学] R971.2[医药卫生—外科学]