阻断早产儿乙型肝炎病毒母婴传播的免疫效应  

A immunity effect contrast study of the of interdict the hepatitis B virus from mother to premature infants

作　　者：陈红[1] 李瑛[1] 杨海珊[2] 

机构地区：[1]北京市海淀区妇幼保健院儿科,100080 [2]北京市海淀区妇幼保健院检验科,100080

出　　处：《中国优生与遗传杂志》2010年第2期57-59,共3页Chinese Journal of Birth Health & Heredity

基　　金：北京市卫生局妇幼科研基金资助项目(C03011403)

摘　　要：目的为了了解不同免疫方式对母亲为乙肝病毒携带者婴儿早产儿方案的免疫效应。方法将在我院分娩的母亲为乙肝病毒携带者,孕周小于37周,出生体重小于2500g的早产儿作为观察对象,并将同期出生的母亲为乙肝病毒携带者足月儿作为对照。分组:①早产1组为母亲在孕期用过HBIG的早产儿,早产2组为母亲在孕期未用过HBIG的早产儿。早产1组和早产2组早产儿生后注射乙肝免疫球蛋白(HBIG)200IU,生后2～4周重复1次,生后2、3、6个月各接种乙肝疫苗10μg。②足月1组为母亲在孕期用过HBIG的足月儿,足月2组为母亲在孕期未用过HBIG的足月儿。③对照1、2、3组为在1岁时检测乙肝表面抗体的母亲为乙肝病毒携带者的足月儿。对照1组为母亲在孕期用过HBIG的足月儿,对照2组为母亲在孕期未用过HBIG的足月儿。对照1组和对照2组生后注射HBIG200IU,生后2～4周重复1次,对照3组为母亲在孕期未用过HBIG生后新生儿也未用过HBIG的足月儿。各对照组足月儿出生后0、1、6月各接种乙肝疫苗剂量10μg。观察项目:①乙肝病毒携带者孕妇早产发生率。②检测生后24h内静脉血乙肝病毒抗原。③观察生后乙肝病毒抗原为阴性的婴儿生后1岁乙肝保护性抗体乙肝表面抗体(HBsAb)定量检测,定量大于100mIU/ml为强应答,小于100mIU/ml为弱应答。④观察生后1岁乙肝抗原乙肝表面抗原(HBsAg)和乙肝e抗原(HBeAg)定性。结果①乙肝病毒携带者孕妇早产发生率为5.30%。②早产儿47例生后检测乙肝病毒抗原为阳性者2例,阳性率为4.25%,同期足月新生儿840例,乙肝病毒抗原为阳性者9例,阳性率为1.07%,早产儿与足月儿出生时乙肝病毒抗原阳性率率差异无显著性(χ2=3.684,P=0.055)。③早产1组生后1岁19例早产儿有12例(63.2%)HBsAb定量为强应答,早产2组26例早产儿有17例(65.4%)HBsAb定量为强应答,两组早产儿HBsAb定量检测免疫效应差异无显著�Objective：To research immunity responsion a method of interrupting the hepatitis B virus transmission from mother to premature infants in Beijing planned immunity procedure Method：The premature and time full-term neonate whose mother was carrier with the hepatitis B virus were observed. In the premature 1 group the premature infants whose mother was injected the hepatitis B immunoglobulin（HBIG） during pregnant. In the 2 group the premature infants whose mother was not injected the hepatitis B immunoglobulin（HBIG） during pregnant. In the premature 1 group and the premature 2 group after birth the premature infants were injected the hepatitis B immunoglobulin（HBIG） 200IU ,after 2-4 weeks same dose were repeatedly injected 1 times,moreover they were inoculated the hepatitis B vaccine 10μg at 2,3,6 month after birth. In three contrast group there were full-term infant all. In contrast 1 group the full-term neonate whose mother was injected the hepatitis B immunoglobulin （HBIG） during pregnant. In the contrast 2 group the full-term neonate whose mother was not injected the hepatitis B immunoglobulin（HBIG） during pregnant. In the contrast 1 group and the contrast 2 group the full-term neonate were injected the hepatitis B immunoglobulin（HBIG） 200IU ,after 2-4 weeks same dose were repeatedly injected 1 times. In the contrast 3 group full-term neonate whose mother was not injected the hepatitis B immunoglobulin（HBIG） during pregnant and themselves was not injected the hepatitis B immunoglobulin（HBIG） after birth. In every contrast group the full-term neonate were inoculated the hepatitis B vaccine 10μg at 0,1,6 month after birth respectively. When 1 years the protective antibody HBsAb quantify and the hepatitis B antigen HBsAg and HBeAg quality of all children vein blood were tested. The protective antibody HBsAb quantify more than 100mIU/ml is strong responsion and less than 100mIU/ml is weak responsion. Result： ①The newborn whose mother was carrier with the hepatitis B virus pr

关 键 词：乙型肝炎病毒 阻断 传播 母亲 早产儿 免疫应答 

分 类 号：R722.6[医药卫生—儿科]