胱抑素C检测对过敏性紫癜早期肾损伤的诊断价值  

Diagnostic value of cystatin C detection for the early renal injury in children with Henoch-Schonlein purpura

作　　者：梁任[1] 陈恺杰[1] 黄宇戈[1] 

机构地区：[1]广东医学院附属医院,广东湛江524001

出　　处：《海南医学》2010年第5期10-12,共3页Hainan Medical Journal

摘　　要：目的探讨血清胱抑素C(CysC)水平对过敏性紫癜(HSP)早期肾功能损害的临床价值。方法对48名过敏性紫癜患者分别采用乳胶颗粒增强透射免疫比浊法(PETIA)测定血清CysC水平,采用免疫透射比浊法检测尿微量白蛋白排泄率(Urine albumin excretion rate,UAER),采用氧化酶法测定血Scr水平,并与20例对照组比较分析。结果过敏性紫癜患儿血清CysC水平随着UAER的升高而升高,各组之间比较差异均有统计学意义(P<0.05,P<0.01);血清CysC与UAER、Scr呈显著正相关(P<0.01,P<0.05);UAER正常组和UAER异常组的血清CysC异常率均显著高于Scr的异常率(P<0.05,P<0.01)。结论血清CysC的测定对过敏性紫癜早期肾损伤的诊断具有良好的临床价值。Objective To study the clinical value of serum Cys C levels in the patients with nonage renal function injury caused by Henoch - Sehordein purpura. Methods Using radloimmouology analytic technique to measure the blood levels of cystatin C and urine albumin excretion rate（ UAER）, and using enzymic method to detect Scr levels in serum in 48 children with Henoch - Schonlein purpura. Results The levels of serum Cys C in the HSP groups were slganificantly higher than those in control group（ P 〈 0.05, D 〈 0.0] ） , and the serum Cys C levels increased when the urine albumin excretion rate （UAER） increased. The levels of Cys C was positively correlated with UAER and Scr （P 〈0.01 ,P 〈0.05）. Abnormal rate of Cys C was higer than that of Scr in children with Henoch - Schonlein purpura （ P 〈 0.01, P 〈 0.05 ）. Conclusion Serum Cys C has important clinical value in the early diagnosis of renal injury in children with Henoch - Schonlein purpura.

关 键 词：胱抑素C 过敏性紫癜 肾损伤 放射免疫测定 

分 类 号：R554.6[医药卫生—血液循环系统疾病]