L-选择素在白细胞活化中的作用  

The function of L-selectin in the leukocyte activation

作　　者：陈翠霞[1] 崔凌凌[2] 尚新[2] 曾宪录[2] 

机构地区：[1]中国石油大学(华东)生物工程与技术中心,青岛266555 [2]东北师范大学遗传与细胞研究所,长春130024

出　　处：《生命科学》2010年第1期79-83,共5页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(30900765);中国石油大学(华东)博士基金(UPC-b)

摘　　要：白细胞沿着血管内皮滚动、稳定黏附,最终到达炎症部位是一个复杂的、多步骤的过程,该过程需要众多分子协同完成。选择素家族分子对于白细胞沿着血管内皮的滚动起重要作用。L-选择素是选择素家族的一员,组成性的表达在白细胞微绒毛顶端,在白细胞沿血管内皮起始黏附过程中起主要作用。除具有黏附作用外,L-选择素还作为信号分子在黏附事件中发挥作用。该文结合作者的研究工作,综述了L-选择素在白细胞活化过程中的功能。Lymphocyte recruitment onto inflamed tissues requires cells tethering to and rolling on vascular surfaces under flow. Recruitment of leukocytes is controlled by a variety of adhesion molecules expressing on the surface of the endothelium and circulating leukocytes. The members of selectin family play important roles during the lymphocytes rolling on the vessel. L-selectin, a member of selectin family and constitutively expressing on leukocytes, plays a fundamental role in the lymphocyte tethering on the vessel. Except for its role in adhesion, L-selectin can serve as a signal transduction molecule. We review the function of L-selectin in the leukocyte activation from its structure, adhesion and signal transduction functions here.

关 键 词：细胞黏附 L-选择素 激酶 信号转导 

分 类 号：R329.25[医药卫生—人体解剖和组织胚胎学] R332.13[医药卫生—基础医学]