高血压患者左心室功能及肾脏血流动力学与瘦素受体基因外显子4Lys109Arg变异的关系  

Relationship between the mutation of the exon 4 of leptin receptor gene and left ventricular function and renal hemodynamics in patients with hypertension

作　　者：王楠[1] 成蓓[2] 马丽雅[1] 

机构地区：[1]甘肃省人民医院干三科,兰州730001 [2]华中科技大学附属协和医院干部病房

出　　处：《中国医师进修杂志》2010年第1期13-15,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨高血压患者的左心室功能、肾脏血流动力学指标与瘦素受体（LR）基因外显子4Lys109Arg变异的关系。方法2005年12月至2006年12月，用地高辛标记引物酶显色法检测高血压患者90例（高血压组）及健康人52例（健康对照组）LR基因外显子4Lys109Arg的变异情况。同时应用彩色多普勒超声仪检测两组的左心室功能[左心室射血分数（LVEF）、左心室短轴缩短率（LVFS）、左心室舒张早期流速峰值与左心室舒张晚期流速峰值比（E/A）]、肾脏血流动力学指标[肾动脉主干收缩期最大流速（Vmax）、舒张期血管内径（ID）、阻力指数（RI）、搏动指数（PI）]，并进行比较分析。结果LR基因外显子4Lys109Arg变异的不同基因型在高血压组与健康对照组之间频率分布比较差异无统计学意义；高血压组与健康对照组AA基因型各项指标比较差异无统计学意义；GG基因型在LVEF、E／A、LVFS、RI和PI指标比较差异有统计学意义（P〈0．05）；GA基因型在LVEF、E／A和LVFS指标比较差异有统计学意义（P〈0．05）。高血压组GG基因型与AA基因型在LVEF、E／A、LVFS、RI和H指标比较差异有统计学意义（P〈0．05）。健康对照组GG基因型与AA基因型在RI指标比较差异有统计学意义（O．65±0．02比0．63±0．02，P〈0．05）。结论左心室功能、肾脏血流动力学指标的变化与LR基因外显子4Lys109Arg的变异有关。Objective To investigate the relationship between the mutation of the exon 4 of leptin receptor gene （4Lys109Arg） and left ventricular function and renal hemodynamies in patients with hypertension. Methods From December 2005 to December 2006, digoxin marked primer enzyme coloration technique was used to detect the 4Lys109Arg polymorphism. The color Doppler echocardiography was used to detect the left ventricular function and the renal hemedynamics. The study covered 90 patients with hypertension （hypertension group） and 52 controls （control group）. Results The frequencies of 4Lys109Arg in hypertension group and control group had no significant difference. The hypertension with GG genotype was significant difference in left ventricular ejection fraction（LVEF） ,E/A, left ventricular fractional shortening （LVFS）,resistance index （RI）,pulsatility index （PI）（P 〈 0.05）. The hypertension with GA genotype had significant difference in LVEF,E/A,LVFS （P 〈0.05）. In hypertension group,LVEF,E/A, LVFS, RI and PI had significant difference between GG and AA genotype（P 〈 0.05 ）. In control goup, RI had significant difference between GG and AA genotype （0.65 ± 0.02 vs 0.63 ± 0.02,P 〈 0.05）. Conclusion The renal hemodynamics and the left ventricular function are associated with 4Lys109Arg polymorphism.

关 键 词：高血压 心室功能 左 肾脏血流动力学 瘦素受体基因 

分 类 号：R544[医药卫生—心血管疾病]