50岁以下女性冠心病的临床和冠状动脉造影特点  

Clinical and coronary angiographic characteristics in women less than 50 years with coronary heart disease

作　　者：陈晖[1] 姚道阔[1] 张欣[1] 郑志昌[1] 周力[1] 王国栋[1] 韩炜[1] 李虹伟[1] 

机构地区：[1]首都医科大学附属北京友谊医院心血管中心,100050

出　　处：《中国医师进修杂志》2010年第1期25-27,共3页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨50岁以下女性冠心病患者的危险因素、临床和冠状动脉造影特点。方法连续入选2000年4月至2008年6月行冠状动脉造影的50岁以下女性患者126例，回顾性分析女性冠心病患者的危险因素、临床及冠状动脉病变特点。结果同期行冠状动脉造影6395例，50岁以下女性患者126例，占1．97％，其中冠心病患者44例（冠心病组），平均年龄（46．8±3．6）岁；非冠心病患者82例（非冠心病组），平均年龄（45．4±4．3）岁。两组合并原发性高血压[77．3％（34144）比26．8％（22／82）]、糖尿病[34．1％（15144）比4．9％（4／82）]、高脂血症[43．2％（19／44）比7．3％（6／82）]、冠心病家族史[43．2％（19／44）比7．3％（6，82）]及冠心病危险因素家族史[52．3％（23／44）比12．2％（10／82）]比较差异有统计学意义（P〈0．01）。冠心病患者以急性冠脉综合征为主[占88．6％（39144）]，冠状动脉病变以单支病变多见[占50．0％（22／44）]，左前降支是最易累及的血管，病变钙化程度较轻，病变类型以局限性和节段性为主。结论原发性高血压、高脂血症、糖尿病、冠心病家族史及冠心病危险因素家族史为50岁以下女性冠心病的重要危险因素。有典型心绞痛症状伴有多重危险因素者，患冠心病的可能性增大。Objective To investigate the risk factors,clinical and coronary angiographic characteristics in women less than 50 years with coronary heart disease （CHD）. Methods One hundred and twenty-six women less than 50 years were divided into CHD group and non-CHD group according to the result of coronary angiography （CAG）. Risk factors, clinical and coronary angiographic characteristics were investigated retrospectively. Results In 6395 cases who were given CAG in the corresponding time period, 126 （1.97%） women were less than 50 years, and 44 cases were confirmed as having CHD by CAG[ CHD group, mean age （46.8 ± 3.6） years ） ]. Meanwhile 82 cases were in non-CHD group [ mean age （45.4 ± 4.3 ） years ） ]. The incidence rate of hypertension [ 77.3% （34/44） vs 26.8% （22/82） ], diabetes mellitus [ 34.1% （15/44） vs 4.9%（4/82）], hyperlipidemia [43.2%（19/44） vs 7.3%（6/82）] ,family history of CHD[43.2% （19/44） vs 7.3%（6/82） ],and risk factors of family history of CHD [52.3%（23/44） vs 12.2%（10/82）] had significant difference between CHD group and non-CHD group（P〈 0.01 ）. 88.6%（39/44） CHD patients were acute coronary syndrome, 50.0%（20/44） lesion was one-vessel lesion. Left anterior descending coronary was involved most easily. The degree of calcification was lighter. The type of lesion was mostly localized and segmented. Conclusions Hypertension,hyperlipidemia,diabetes mellitus, family history of CHD,and risk factors of family history of CHD are the major risk factors in women less than 50 years with CHD. The possibility of CHD is higher when having classical angina and multiple risk factors.

关 键 词：冠状动脉疾病 危险因素 女性 中青年 

分 类 号：R541.4[医药卫生—心血管疾病]