两种复吸动物模型的神经生物学机制  

Neurobiological Mechanisms of Two Animal Models of Relapse

作　　者：钱玲玲[1] 朱永平[1] 

机构地区：[1]浙江大学医学院毒理研究室,杭州310058

出　　处：《中国实验动物学报》2010年第1期81-86,共6页Acta Laboratorium Animalis Scientia Sinica

基　　金：国家重点基础研究发展计划项目(973计划)(2003CB515402);浙江省科技计划重点项目(2005C23G2010166);卫生部科学研究基金(省部共建项目计划)(WKJ2007-2-007)

摘　　要：复吸是指撤药一段时间后,觅药和用药行为的恢复。它是药物成瘾的主要特征之一,也是药物成瘾治疗亟待解决的头号难题。本文介绍两种复吸动物模型——自身给药消退恢复模型、条件性位置偏爱消退复燃模型建立的方法,对模型的效标效度进行评价,探讨复吸的神经生物学机制,为药物成瘾的治疗提供研究思路。Relapse is the reinstatement of drug-seeking and drug-taking behaviors following a period of abstinence.It is one of the main characteristics of drug addiction and is also the major problem requiring immediate action for the treatment of drug addiction.In this review,in order to offer new ideas to eventually treat drug addiction,efforts are made to describe the establishment of two animal models of relapse — the drug self-administration（SA） and extinction-reinstatement procedure,and the drug-conditioned place preference（CPP） and extinction-reactivation procedure.Then attention is given to assess the criterion validity of the animal models of relapse and to explore the neurobiological mechanisms involved in relapse.

关 键 词：成瘾 复吸 药物依赖 动物模型 效标效度 

分 类 号：R332[医药卫生—人体生理学]