骨骼肌P2受体的功能与疾病  

Function of P2 receptors in skeletal muscle and their roles in the diseases

作　　者：徐昌水[1] 高云[1] 梁尚栋[1] 

机构地区：[1]南昌大学基础医学院生理学教研室,江西南昌330006

出　　处：《中国药理学通报》2010年第2期144-147,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30860086;30860333;30660048);教育部高校博士点专项科研基金课题(No20070403007);江西省自然科学基金课题(No0640042;2008GZY0029);江西省教育厅科研基金课题(No2007-60;GJJ08049);江西省优秀博士学位论文培育基金(NoYBP08A01);江西省(南昌大学)研究生创新基金资助课题(NoYC08B009)

摘　　要：嘌呤和嘧啶核苷酸作用的P2受体分为G蛋白偶联型的P2Y受体和配体门控离子通道型的P2X受体。研究表明,骨骼肌细胞有多种P2X和P2Y受体亚型表达。嘌呤信号在肌肉萎缩症的肌肉再生中具有重要的作用,与肌肉萎缩症、肌腱炎等骨骼肌疾病有关,并可能为治疗与肌肉有关的疾病提供新的治疗策略。P2 receptors activated by purine and pyrimidine nucleotides are divided into two subclasses： P2Y receptors which are G-protein coupled and P2X receptors which are ligand-gated ion channels. The expression of specific P2X and P2Y receptor subtypes in skeletal muscle cells has been demonstrated. Purinergic signaling plays an important role in muscle regeneration of muscular dystrophy, and is involved in skeletal muscle diseasessuch as muscular dystrophy, tendon inflammation and epilepsy, and provides the possibility of new therapeutic strategies for the treatment of muscle diseases.

关 键 词：P2受体 胞外嘌呤核苷酸 胞外嘧啶核苷酸 骨骼肌 神经-肌接头 骨骼肌疾病 

分 类 号：R322.74[医药卫生—人体解剖和组织胚胎学] R392.11[医药卫生—基础医学]